Evidence map›Paper›PMID 34609036›Full record

ArticleNMR in biomedicine2022

Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B

Bernhard Strasser, Nicolas S Arango, Jason P Stockmann, Borjan Gagoski, Bijaya Thapa, Xianqi Li, Wolfgang Bogner, Philipp Moser, Julia Small, Daniel P Cahill and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in NMR in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Accelerated Navigator for Rapid ∆BNMR in biomedicine · 2025
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  3. Article
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  5. Real-time motion correction and multicoil shim array B0 update for whole-brain MR spectroscopic imaging.Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition · 2024
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Bernhard StrasserA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Radiology, Boston, Massachusetts, USA.
Nicolas S ArangoDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jason P StockmannA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Radiology, Boston, Massachusetts, USA.
Borjan GagoskiFetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Bijaya ThapaA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Radiology, Boston, Massachusetts, USA.
Xianqi LiA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Radiology, Boston, Massachusetts, USA.
Wolfgang BognerHigh-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Vienna, Austria.ORCID 0000-0002-0130-3463
Philipp MoserHigh-Field MR Centre, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Vienna, Austria.
Julia SmallDepartment of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Daniel P CahillDepartment of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.
Tracy T BatchelorDepartment Neurology, Division of Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jorg DietrichDepartment Neurology, Division of Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Andre van der KouweA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Radiology, Boston, Massachusetts, USA.
Jacob WhiteDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Elfar AdalsteinssonDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Ovidiu C AndronesiA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Radiology, Boston, Massachusetts, USA.ORCID 0000-0002-7412-0641
Massachusetts General Hospital · USHarvard University · USMassachusetts Institute of Technology · USBoston Children's Hospital · USMedical University of Vienna · AT

Funding

Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Benjamin Harris Kann · 2013 to 2026
$33.5M
Development of whole-brain in vivo 2HG imaging for precision medicine in mutant IDH gliomaR01CA211080 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Ovidiu C Andronesi · 2017 to 2026
$5.4M
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patientsR01CA255479 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDRONESI, OVIDIU C · 2021 to 2025
$3.0M
Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infantsR01HD093578 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HOLMES, MARTHA, KABA, MAMADOU · 2017 to 2022
$2.9M
Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescenceR01HD099846 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2019 to 2023
$2.7M
Neonatal imaging as an early marker of neurodevelopment and predictor of cognitive performance in infants exposed to HIV and ART in utero and perinatallyR01HD085813 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2016 to 2020
$2.3M
Open-source software and hardware tools for local B0 field controlU24EB028984 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI STOCKMANN, JASON P · 2019 to 2021
$964k
Improved imaging of deep brain nuclei with 7 Tesla MRI using comprehensive magnetic field monitoringR00EB021349 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI STOCKMANN, JASON P · 2018 to 2020
$747k
Combined shim-RF for improved high field MRIR21EB017338 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 2013 to 2014
$472k
Austrian Science Fund FWF J 4124NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA211080NCI NIH HHS R01 CA255479NIBIB NIH HHS R00 EB021349NIBIB NIH HHS R21 EB017338NIBIB NIH HHS U24 EB028984NICHD NIH HHS R01 HD085813NICHD NIH HHS R01 HD093578NICHD NIH HHS R01 HD099846
6 · The paper itself

Abstract

MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance of full field-of-view MRSI is limited by B

Indexed as

AdultBrain NeoplasmsFemaleGliomaGlutaratesHumansIsocitrate DehydrogenaseMagnetic Resonance ImagingMaleMutationalpha-hydroxyglutarateGlutaratesIsocitrate DehydrogenaseD-2-hydroxyglutarateglioma brain tumorisocitrate dehydrogenase mutationsmagnetic resonance spectroscopic imagingmulticoil shimmingmultiplexed RF-receive and B0-shim arrayprecision oncology

Identifiers

PMID34609036
PMCPMC8717863
OpenAlexW3204860448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.