ArticlePlant physiology2021
Regulation of carotenoid and chlorophyll pools in hesperidia, anatomically unique fruits found only in Citrus.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Carotenoid aggregates negatively impact chlorophyll levels and disrupt chloroplast development in peaches.Molecular horticulture · 2026Article
- Integrative analysis of the metabolome and transcriptome reveals the mechanism of flower color and antioxidant capacity in threeFrontiers in plant science · 2026Article
- Integrated metabolomic and transcriptomic analysis of the mechanism underlying pericarp variegation inFrontiers in plant science · 2026Article
- A Study on the Cell Layer Patterns of a Citrus Periclinal Chimera Reveals β-Cryptoxanthin Regulation in Citrus Fruits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cucumber Green Mottle Mosaic Virus Decreases ChlorophyllPlants (Basel, Switzerland) · 2025Article
- Spatial regulation of chlorophyll degradation in kiwifruit: AcNAC2-AcSGR1/2 cascades mediate rapid de-greening in the inner pericarp.Plant biotechnology journal · 2025Article
- Transcriptomic and Structural Insights into Leaf Variegation Development inInternational journal of molecular sciences · 2025Article
- Integrated genomic and transcriptomic analysis reveals the mechanisms underlying leaf variegation in 'Gonggan' mandarin.BMC plant biology · 2025Article
- The MADS-Box Transcription Factor CaRIN Positively Regulates Chlorophyll Degradation During Pepper (Plants (Basel, Switzerland) · 2025Article
- BrCYP71 mutation resulted in stay-green in pak choi (Brassica rapa L. ssp. chinensis).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Expression Analysis of Chlorophyll-Degradation-Related Genes inPlants (Basel, Switzerland) · 2025Article
- Phased genomics reveals hidden somatic mutations and provides insight into fruit development in sweet orange.Horticulture research · 2024Article
- Volatile metabolomics and transcriptomics analyses provide insights into the mechanism of volatile changes during fruit development of 'Ehime 38' (Frontiers in plant science · 2024Article
- Integrated transcriptome and metabolome analysis unveils the mechanism of color-transition in Edgeworthia chrysantha tepals.BMC plant biology · 2023Article
- Transcription factor CsTT8 promotes fruit coloration by positively regulating the methylerythritol 4-phosphate pathway and carotenoid biosynthesis pathway in citrus (Horticulture research · 2023Article
- Transcription factor LcNAC002 coregulates chlorophyll degradation and anthocyanin biosynthesis in litchi.Plant physiology · 2023Article
- Jasmonate activates a CsMPK6-CsMYC2 module that regulates the expression of β-citraurin biosynthetic genes and fruit coloration in orange (Citrus sinensis).The Plant cell · 2023Article
- CitrusHorticulture research · 2023Article
- The transcription factor IbNAC29 positively regulates the carotenoid accumulation in sweet potato.Horticulture research · 2023Article
- A chromosome-level phased genome enabling allele-level studies in sweet orange: a case study on citrus Huanglongbing tolerance.Horticulture research · 2023Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domesticated citrus varieties are woody perennials and interspecific hybrid crops of global economic and nutritional importance. The citrus fruit "hesperidium" is a unique morphological innovation not found in any other plant lineage. Efforts to improve the nutritional quality of the fruit are predicated on understanding the underlying regulatory mechanisms responsible for fruit development, including temporal control of chlorophyll degradation and carotenoid biosynthesis. Here, we investigated the molecular basis of the navel orange (Citrus sinensis) brown flavedo mutation, which conditions flavedo that is brown instead of orange. To overcome the limitations of using traditional genetic approaches in citrus and other woody perennials, we developed a strategy to elucidate the underlying genetic lesion. We used a multi-omics approach to collect data from several genetic sources and plant chimeras to successfully decipher this mutation. The multi-omics strategy applied here will be valuable in driving future gene discovery efforts in citrus as well as in other woody perennial plants. The comparison of transcriptomic and genomic data from multiple genotypes and plant sectors revealed an underlying lesion in the gene encoding STAY-GREEN (SGR) protein, which simultaneously regulates carotenoid biosynthesis and chlorophyll degradation. However, unlike SGR of other plant species, we found that the carotenoid and chlorophyll regulatory activities could be uncoupled in the case of certain SGR alleles in citrus and thus we propose a model for the molecular mechanism underlying the brown flavedo phenotype. The economic and nutritional value of citrus makes these findings of wide interest. The strategy implemented, and the results obtained, constitute an advance for agro-industry by driving opportunities for citrus crop improvement.
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