ArticleeLife2021
Protective mitochondrial fission induced by stress-responsive protein GJA1-20k.
Abstract read
In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Loss of connexin 43 in cartilage causes mitochondrial dysfunction and accelerates post-traumatic osteoarthritis progression.bioRxiv : the preprint server for biology · 2026Article
- Reversing diastolic dysfunction in diabetes: a mitochondrial quality control-centric pharmacological approach.Acta diabetologica · 2026Review
- Metabolic adaptation of regenerative hematopoiesis depends on docking-independent mitochondrial connexin 43.Blood · 2025Article
- Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex.The Journal of cell biology · 2025Article
- Left Ventricular Unloading With Assist Device Implantation Increases GJA1-20k Expression in Patients With Arrhythmogenic Cardiomyopathy.Circulation. Heart failure · 2025Article
- DRP1, fission and apoptosis.Cell death discovery · 2025Review
- A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43.The Journal of cell biology · 2025Article
- Review
- Review
- Should it stay or should it go: gap junction protein GJA1/Cx43 conveys damaged lysosomes to the cell periphery to potentiate exocytosis.Autophagy · 2024Article
- Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes.Stem cell research & therapy · 2024Article
- Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling.The EMBO journal · 2024Article
- Cx43-mediated hyphal folding counteracts phagosome integrity loss during fungal infection.Microbiology spectrum · 2023Article
- Convergent and divergent mechanisms of peroxisomal and mitochondrial division.The Journal of cell biology · 2023Article
- The multiple links between actin and mitochondria.Nature reviews. Molecular cell biology · 2023Review
- Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC.PLoS genetics · 2023Article
- The Role of Mitochondria in Mediation of Skeletal Muscle Repair.Muscles (Basel, Switzerland) · 2023Review
- Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress.Cellular & molecular biology letters · 2022Article
- Review
- Mitochondrial dysfunction in vascular endothelial cells and its role in atherosclerosis.Frontiers in physiology · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Daisuke ShimuraNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.ORCID 0000-0002-9954-2162
Esther NuebelHoward Hughes Medical Institute, University of Utah, Salt Lake City, United States.
Rachel BaumNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.
Steven E ValdezNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.
Shaohua XiaoDepartment of Neurology, University of California at Los Angeles, Los Angeles, United States.
Junco S WarrenNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.
Joseph A PalatinusNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.
TingTing HongNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.
Jared RutterHoward Hughes Medical Institute, University of Utah, Salt Lake City, United States.ORCID 0000-0002-2710-9765
Robin M ShawNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, United States.ORCID 0000-0001-7429-6092
Funding
Novel Mechanisms of Cardiac Ion Channel RegulationR01HL094414 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAW, ROBIN M · 2009 to 2018
$3.6MMitochondrial Biochemistry: From Mechanisms to DiseaseR35GM131854 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 2019 to 2026
$3.3MAnalysis of Nematode Sex Determination and Dosage CompensationR35GM131845 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MEYER, BARBARA J · 2019 to 2023
$2.3MRegulation of Cav1.2 Trafficking by GJA1-20k and cBIN1R01HL159983 · NHLBI · UNIVERSITY OF UTAH · PI HONG, TINGTING, SHAW, ROBIN M · 2021 to 2024
$2.2MRegulation of Ion Channels at BIN1-induced T-tubule MicrodomainsR01HL133286 · NHLBI · UNIVERSITY OF UTAH · PI HONG, TINGTING · 2016 to 2020
$2.2MA New Non-Canonical Role for an Alternatively Translated Ion Channel ProteinR01HL138577 · NHLBI · UNIVERSITY OF UTAH · PI SHAW, ROBIN M · 2017 to 2020
$2.1MUnlocking Trafficking Specificity for Cx43 Gap JunctionsR01HL152691 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Robin M Shaw · 2020 to 2026
$2.0MTargeting Protein Trafficking in Arrhythmogenic CardiomyopathyK08HL155886 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI PALATINUS, JOSEPH A. · 2021 to 2025
$896kAdvancing cBIN1 Therapy to Large Preclinical AnimalsR21AG074593 · NIA · UNIVERSITY OF UTAH · PI HONG, TINGTING, SHAW, ROBIN M · 2021 to 2022
$419kHoward Hughes Medical InstituteNHLBI NIH HHS K08 HL155886NHLBI NIH HHS R01 HL094414NHLBI NIH HHS R01 HL133286NHLBI NIH HHS R01 HL138577NHLBI NIH HHS R01 HL152691NHLBI NIH HHS R01 HL159983NIA NIH HHS R21 AG074593NIGMS NIH HHS R35 GM131845NIGMS NIH HHS R35 GM131854
Abstract
The Connexin43 gap junction gene
Indexed as
AnimalsConnexin 43HEK293 CellsHumansMaleMiceMice, Inbred C57BLMitochondriaMitochondrial DynamicsMyocardial InfarctionMyocytes, CardiacReactive Oxygen SpeciesConnexin 43GJA1 protein, humanGJA1 protein, mouseReactive Oxygen Speciesactin dynamicscell biologyGJA1-20khumanischemia/reperfusionmitochondriamitochondria dynamicsmouseorgan protection
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.