Evidence map›Paper›PMID 34608576›Full record

ArticleEuropean radiology experimental2021

Accuracy and precision of volumetric bone mineral density assessment using dual-source dual-energy versus quantitative CT: a phantom study.

Vitali Koch, Nils Große Hokamp, Moritz H Albrecht, Leon D Gruenewald, Ibrahim Yel, Jan Borggrefe, Stefan Wesarg, Katrin Eichler, Iris Burck, Tatjana Gruber-Rouh and 12 more

Open access · goldAbstract read
In one paragraph

Article in European radiology experimental, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

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  6. Advancing bone health evaluation in Hermann's tortoises (Frontiers in veterinary science · 2026
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  8. Improved muscle and fat segmentation for body composition measures on quantitative CT.International journal of computer assisted radiology and surgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Vitali KochDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Nils Große HokampDepartment of Diagnostic and Interventional Radiology, University Hospital Cologne, Cologne, Germany.
Moritz H AlbrechtDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. Moritz.Albrecht@kgu.de.ORCID 0000-0002-4966-6407
Leon D GruenewaldDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Ibrahim YelDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Jan BorggrefeDepartment of Radiology, Neuroradiology and Nuclear Medicine, Minden Hospital, University of Kiel, Kiel, Germany.
Stefan WesargCognitive Computing and Medical Imaging, Fraunhofer IGD, Darmstadt, Germany.
Katrin EichlerDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Iris BurckDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Tatjana Gruber-RouhDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Lukas LengaDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Thomas J VoglDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Simon S MartinDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Julian L WichmannDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Renate M HammerstinglDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Leona S AlizadehDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Christoph MaderDepartment of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Nicole A HuizingaInterdisciplinary Center for Neuroscience, Goethe University of Frankfurt, Frankfurt am Main, Germany.
Tommaso D'AngeloDepartment of Biomedical Sciences and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy.
Giorgio AscentiDepartment of Biomedical Sciences and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy.
Silvio MazziottiDepartment of Biomedical Sciences and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy.
Christian BoozDivision of Experimental Imaging, Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Goethe University Frankfurt · DEUniversity of Messina · ITChristian-Albrechts-Universität zu Kiel · DEFraunhofer Institute for Computer Graphics Research · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDual-source dual-energy computed tomography (DECT) offers the potential for opportunistic osteoporosis screening by enabling phantomless bone mineral density (BMD) quantification. This study sought to assess the accuracy and precision of volumetric BMD measurement using dual-source DECT in comparison to quantitative CT (QCT).

methodsA validated spine phantom consisting of three lumbar vertebra equivalents with 50 (L1), 100 (L2), and 200 mg/cm

resultsDECT-derived BMD values differed significantly from those obtained by QCT (p < 0.001) and were found to be closer to true HA concentrations. Relative measurement errors were significantly smaller for DECT in comparison to QCT (L1, 0.94% versus 9.68%; L2, 0.28% versus 5.74%; L3, 0.24% versus 3.67%, respectively). DECT demonstrated better BMD measurement repeatability compared to QCT (coefficient of variance < 4.29% for DECT, < 6.74% for QCT). Both methods correlated well to each other (r = 0.9993; 95% confidence interval 0.9984-0.9997; p < 0.001) and revealed substantial agreement in Bland-Altman plots.

conclusionsPhantomless dual-source DECT-based BMD assessment of lumbar vertebra equivalents using material decomposition showed higher diagnostic accuracy compared to QCT.

Indexed as

Bone DensityTomography, X-Ray ComputedAbsorptiometry, PhotonLumbar VertebraePhantoms, ImagingBone densityDual-energy computed tomographyOsteoporosisPhantoms (imaging)Tomography (x-ray computed)

Identifiers

PMID34608576
PMCPMC8490583
OpenAlexW3201754196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.