ArticleNature neuroscience2021
Precisely timed theta oscillations are selectively required during the encoding phase of memory.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Decoding Medial Entorhinal Cortical Dynamics Produces Planning-Like Alternations in Hippocampal theta Sequences.Hippocampus · 2026Article
- Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.Cell reports · 2026Article
- Sleep lowers waking theta frequency in the rat hippocampus.Cell reports · 2026Article
- Magnetic resonance identification tags for ultra-flexible electrodes.Nature communications · 2026Article
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- Olfactory-to-Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency-Specific Oscillatory Decoupling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.bioRxiv : the preprint server for biology · 2025Article
- Time cell sequences during delay intervals are not dependent on brain state and do not support hippocampus-dependent working memory.Nature communications · 2025Article
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- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Closed-loop control of theta oscillations enhances human hippocampal network connectivity.Nature communications · 2025Article
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Right posterior theta reflects human parahippocampal phase resetting by salient cues during goal-directed navigation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Development of the SPEAR Model: Separate Phases of Encoding and Retrieval Are Necessary for Storing Multiple Overlapping Associative Memories.Hippocampus · 2025Review
- Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory.bioRxiv : the preprint server for biology · 2024Article
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- Optogenetic Stimulation of CA1 Pyramidal Neurons at Theta Enhances Recognition Memory in Brain Injured Animals.Journal of neurotrauma · 2023Article
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Authors and funding
12 authors.
Funding
Abstract
Brain oscillations have been hypothesized to support cognitive function by coordinating spike timing within and across brain regions, yet it is often not known when timing is either critical for neural computations or an epiphenomenon. The entorhinal cortex and hippocampus are necessary for learning and memory and exhibit prominent theta oscillations (6-9 Hz), which are controlled by pacemaker cells in the medial septal area. Here we show that entorhinal and hippocampal neuronal activity patterns were strongly entrained by rhythmic optical stimulation of parvalbumin-positive medial septal area neurons in mice. Despite strong entrainment, memory impairments in a spatial working memory task were not observed with pacing frequencies at or below the endogenous theta frequency and only emerged at frequencies ≥10 Hz, and specifically when pacing was targeted to maze segments where encoding occurs. Neural computations during the encoding phase were therefore selectively disrupted by perturbations of the timing of neuronal firing patterns.
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