Evidence map›Paper›PMID 34608240›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2022

ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis.

Kailiang Zhang, Rong Bao, Fengyuan Huang, Kevin Yang, Yishu Ding, Lothar Lauterboeck, Masasuke Yoshida, Qinqiang Long, Qinglin Yang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Kailiang Zhang *Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rong Bao *Cardiovascular Center of Excellence and Department of Pharmacology, Louisiana State University Health Science Center New Orleans, New Orleans, LA, USA.
Fengyuan HuangDepartment of Nutrition Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Kevin YangDepartment of Nutrition Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Yishu DingDepartment of Nutrition Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Lothar LauterboeckCardiovascular Center of Excellence and Department of Pharmacology, Louisiana State University Health Science Center New Orleans, New Orleans, LA, USA.
Masasuke YoshidaDepartment of Molecular Bioscience, Kyoto Sangyo University, Kamigamo-Motoyama, Kyoto, Japan.
Qinqiang LongDivision of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. longqq@gdpu.edu.cn.ORCID 0000-0001-9036-8535
Qinglin YangCardiovascular Center of Excellence and Department of Pharmacology, Louisiana State University Health Science Center New Orleans, New Orleans, LA, USA. qyang1@lsuhsc.edu.
Louisiana State University Health Sciences Center New Orleans · USUniversity of Alabama at Birmingham · USGuangzhou University of Chinese Medicine · CNKyoto Sangyo University · JPTongji Hospital · CN

Funding

Improving Mitochondrial Function to Protect against Myocardial Ischemia/ReperfusionR01HL135336 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YANG, QINGLIN · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL135336
6 · The paper itself

Abstract

Mitochondrial homeostasis is crucial for the function of pancreatic β-cells. ATP synthase inhibitory factor subunit 1 (IF1) is a mitochondrial protein interacting with ATP synthase to inhibit its enzyme activity. IF1 may also play a role in maintaining ATP synthase oligomerization and mitochondrial inner membrane formation. A recent study confirmed IF1 expresses in β-cells. IF1 knockdown in cultured INS-1E β-cells enhances glucose-induced insulin release. However, the role of IF1 in islet β-cells remains little known. The present study investigates islets freshly isolated from mouse lines with global IF1 knockout (IF1

Indexed as

HomeostasisAdenosine TriphosphateAnimalsATPase Inhibitory ProteinCell Line, TumorGlucoseInsulin-Secreting CellsInsulin SecretionIslets of LangerhansMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, Electron, TransmissionMitochondriaAdenosine TriphosphateATPase Inhibitory ProteinGlucoseProteinsReactive Oxygen Species

Identifiers

PMID34608240
PMCPMC9198815
OpenAlexW3201696423

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.