ArticleScientific reports2021
Nonlinear collision between propagating waves in mouse somatosensory cortex.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Touch-evoked traveling waves establish a translaminar spacetime code.Science advances · 2025Article
- Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies.Biosensors · 2023Review
- Cortical propagating waves: amplifying and suppressive?Journal of computational neuroscience · 2021Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How does cellular organization shape the spatio-temporal patterns of activity in the cortex while processing sensory information? After measuring the propagation of activity in the mouse primary somatosensory cortex (S1) in response to single whisker deflections with Voltage Sensitive Dye (VSD) imaging, we developed a two dimensional model of S1. We designed an inference method to reconstruct model parameters from VSD data, revealing that a spatially heterogeneous organization of synaptic strengths between pyramidal neurons in S1 is likely to be responsible for the heterogeneous spatio-temporal patterns of activity measured experimentally. The model shows that, for strong enough excitatory cortical interactions, whisker deflections generate a propagating wave in S1. Finally, we report that two consecutive stimuli activating different spatial locations in S1 generate two waves which collide sub-linearly, giving rise to a suppressive wave. In the inferred model, the suppressive wave is explained by a lower sensitivity to external perturbations of neural networks during activated states.
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