ArticleNature communications2021
Epidermal galactose spurs chytrid virulence and predicts amphibian colonization.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Eukaryotic metagenome-assembled genomes recovered from deep metagenomic sequencing of the seagrass,Microbial genomics · 2026Article
- Differential Immune Responses Correlate With Chytridiomycosis Severity in Italian Crested Newts.Molecular ecology · 2026Article
- Infectivity of amphibian chytrid fungi requires metalloprotease-driven spore development and germ tube formation.BMC microbiology · 2026Article
- Bsal susceptibility depends on host origin but not on skin microbiota in captive Pleurodeles waltl.Animal microbiome · 2025Article
- RCA 1-binding glycans as a marker of Batrachochytrium salamandrivorans infection intensity at early stages of pathogenesis.Scientific reports · 2025Article
- In Vitro Infection Model Using A6 Cells Sets the Stage for Host-Journal of fungi (Basel, Switzerland) · 2025Article
- Genome variation in the Batrachochytrium pathogens of amphibians.PLoS pathogens · 2024Review
- Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation.Frontiers in ecology and evolution · 2024Article
- Ecological Barriers for an Amphibian Pathogen: A Narrow Ecological Niche forJournal of fungi (Basel, Switzerland) · 2023Article
- The adaptive microbiome hypothesis and immune interactions in amphibian mucus.Developmental and comparative immunology · 2023Review
- Two-speed genome evolution drives pathogenicity in fungal pathogens of animals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- When Defenses Fail: Atelopus zeteki Skin Secretions Increase Growth of the Pathogen Batrachochytrium dendrobatidis.Integrative and comparative biology · 2022Article
- The beneficial roles of poisonous skin secretions in survival strategies of the odorous frog Odorrana andersonii.Die Naturwissenschaften · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chytrid fungal pathogens Batrachochytrium dendrobatidis and Batrachochytrium salamandrivorans cause the skin disease chytridiomycosis in amphibians, which is driving a substantial proportion of an entire vertebrate class to extinction. Mitigation of its impact is largely unsuccessful and requires a thorough understanding of the mechanisms underpinning the disease ecology. By identifying skin factors that mediate key events during the early interaction with B. salamandrivorans zoospores, we discovered a marker for host colonization. Amphibian skin associated beta-galactose mediated fungal chemotaxis and adhesion to the skin and initiated a virulent fungal response. Fungal colonization correlated with the skin glycosylation pattern, with cutaneous galactose content effectively predicting variation in host susceptibility to fungal colonization between amphibian species. Ontogenetic galactose patterns correlated with low level and asymptomatic infections in salamander larvae that were carried over through metamorphosis, resulting in juvenile mortality. Pronounced variation of galactose content within some, but not all species, may promote the selection for more colonization resistant host lineages, opening new avenues for disease mitigation.
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