Evidence map›Paper›PMID 34608145›Full record

ArticleNature communications2021

A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.

Zhu-Hong Li, Thayer P King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A Vella, Isabelle Coppens, Sandip Patel, Silvia N J Moreno

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Inter-Organellar CaCells · 2025
    Review
  5. Article
  6. Article
  7. The Major Facilitator Superfamily Transporter HAP12 Is Critical inInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. A pyruvate transporter in the apicoplast of apicomplexan parasites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. TheeLife · 2024
    Article
  13. Convergent activation of CaScience signaling · 2023
    Article
  14. Review
  15. Article
  16. The Toxoplasma plant-like vacuolar compartment (PLVAC).The Journal of eukaryotic microbiology · 2022
    Review
  17. Parasite powerhouse: A review of the Toxoplasma gondii mitochondrion.The Journal of eukaryotic microbiology · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhu-Hong LiCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0003-4940-0729
Thayer P KingCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA.
Lawrence AyongCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA.
Beejan AsadyDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Heath, Baltimore, MD, 21205, USA.
Xinjiang CaiDivision of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID 0000-0001-8933-7133
Taufiq RahmanDepartment of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, USA.ORCID 0000-0003-3830-5160
Stephen A VellaCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0002-0626-8708
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Heath, Baltimore, MD, 21205, USA.
Sandip PatelDepartment of Cell and Developmental Biology, University College London, London, WC1E 6BT, UK.ORCID 0000-0001-7247-2013
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, 30602, USA. smoreno@uga.edu.ORCID 0000-0002-2041-6295

Funding

Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
CARDIOVASCULAR SCIENTIST TRAINING PROGRAMT32HL007895 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIVKUMAR, KALYANAM, WATSON, KAROL E · 1998 to 2023
$9.2M
Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Targeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1M
The Toxoplasma apicoplast and calcium signalingR01AI128356 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2017 to 2021
$2.0M
The plant-like vacuole of Toxoplasma gondiiR01AI096836 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2012 to 2016
$1.8M
Biotechnology and Biological Sciences Research Council BB/N01524X/1Biotechnology and Biological Sciences Research Council BB/T015853/1NHLBI NIH HHS T32 HL007895NIAID NIH HHS R01 AI060767NIAID NIH HHS R01 AI096836NIAID NIH HHS R01 AI128356NIAID NIH HHS T32 AI007417NIAID NIH HHS T32 AI060546
6 · The paper itself

Abstract

Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca

Indexed as

Amino Acid SequenceApicoplastsCalciumCalcium ChannelsCalcium SignalingDNAEndoplasmic ReticulumHumansMutationOrganelle BiogenesisPhylogenyProtozoan ProteinsToxoplasmaCalciumCalcium ChannelsDNAProtozoan Proteins

Identifiers

PMID34608145
PMCPMC8490419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.