ArticleNature communications2021
A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 132 citations in OpenAlex.
- A hierarchical, pH-responsive nanocomposite hydrogel platform for synergistic microenvironment reprogramming and attenuation of inflammatory periodontal bone loss.Bioactive materials · 2027Article
- Development of a Polypeptide-Based Platform to Construct Antibody-Drug Conjugates with High Potency.JACS Au · 2026Article
- ROPISA Synthetic Strategy for Photo-Crosslinked Aqueous Polypeptide Nano-Assemblies.Chemistry, an Asian journal · 2026Article
- Sequence-regulated, lung-targeting heteropolypeptide nanoparticles via in situ erythrocyte hitchhiking.Nature communications · 2026Article
- α-Helical peptides: design strategies and recent advances in biomedical applications.Journal of translational medicine · 2026Review
- Mussel-Inspired Catechol-Functionalized Redox-Active Polypeptides for Energy Applications.Biomacromolecules · 2026Article
- A Tandem Chemical Vapor Deposition Platform for the Solvent-Free Synthesis of Polypeptide Architectures.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Potent Racemic Antimicrobial Polypeptides Uncovered by a Stereochemical Series of Cationic d/l Backbones.Journal of the American Chemical Society · 2026Article
- An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- RAFT-Mediated 3D Printing of Polylactones/Itaconate Elastomers with Polypeptide Surface Functionalization.ACS polymers Au · 2025Article
- Versatile Polypeptide-Anchored Antifouling Dip-Coatings for Common Medical Implant Materials.ACS applied materials & interfaces · 2025Article
- Controlled Synthesis and Crystallization-Driven Self-Assembly of Poly(Molecules (Basel, Switzerland) · 2025Article
- A bioinspired and degradable riboflavin-containing polypeptide as a sustainable material for energy storage.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Direct Laser Writing of Selectively Degradable Polypeptide Hydrogel Microstructures by Proteolytic Enzymes.ACS applied materials & interfaces · 2025Article
- Toward Quantitative End-Group Fidelity in the Synthesis of High Molecular Weight Polysarcosine.ACS macro letters · 2025Article
- Unveiling Proton Transfer as the Key Process to Understand and Promote the Ring-Opening Polymerization ofPolymer science & technology (Washington, D.C.) · 2025Review
- Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis.Nature protocols · 2025Review
- Integrating synthetic polypeptides with innovative material forming techniques for advanced biomedical applications.Journal of nanobiotechnology · 2025Review
- Tuning Star Polymer Architecture to Tailor Secondary Structures and Mechanical Properties of Diblock Polypeptide Hydrogels for Direct Ink Writing.Biomacromolecules · 2025Article
- Hot shape transformation: the role of PSar dehydration in stomatocyte morphogenesis.Beilstein journal of organic chemistry · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A great hurdle in the production of synthetic polypeptides lies in the access of N-carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe, and protection of side-chain functional groups. Here we report a robust method for preparing unprotected NCA monomers in air and under moisture. The method employs epoxy compounds as ultra-fast scavengers of hydrogen chloride to allow assisted ring-closure and prevent NCA from acid-catalyzed decomposition under moist conditions. The broad scope and functional group tolerance of the method are demonstrated by the facile synthesis of over 30 different α/β-amino acid NCAs, including many otherwise inaccessible compounds with reactive functional groups, at high yield, high purity, and up to decagram scales. The utility of the method and the unprotected NCAs is demonstrated by the facile synthesis of two water-soluble polypeptides that are promising candidates for drug delivery and protein modification. Overall, our strategy holds great potential for facilitating the synthesis of NCA and expanding the industrial application of synthetic polypeptides.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.