Evidence map›Paper›PMID 34607937›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Anti-PD-1 Checkpoint Therapy Can Promote the Function and Survival of Regulatory T Cells.

Sarah C Vick, Oleg V Kolupaev, Charles M Perou, Jonathan S Serody

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sarah C VickDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC.ORCID 0000-0002-0552-0078
Oleg V KolupaevLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; and.
Charles M PerouLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; and.ORCID 0000-0001-9827-2247
Jonathan S SerodyDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC; jonathan_serody@med.unc.edu.ORCID 0000-0003-4568-1092
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KATHERINE A. HOADLEY · 1992 to 2026
$59.3M
BASIC IMMUNE MECHANISMST32AI007273 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TISCH, ROLAND M · 1985 to 2020
$5.6M
Enhancing Innate Immune Reconstitution Post Allogeneic HSCT.R01HL155098 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan S. Serody · 2021 to 2026
$3.5M
Mechanistic Evaluations of ILC2 Cells for the Treatment/Prevention of GVHDR01HL139730 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SERODY, JONATHAN S. · 2017 to 2020
$2.2M
NCI NIH HHS P30 CA016086NCI NIH HHS P50 CA058223NHLBI NIH HHS R01 HL139730NHLBI NIH HHS R01 HL155098NIAID NIH HHS T32 AI007273
6 · The paper itself

Abstract

We have previously shown in a model of claudin-low breast cancer that regulatory T cells (T

Indexed as

AnimalsImmune Checkpoint InhibitorsLymphocytes, Tumor-InfiltratingMiceMice, Inbred BALB CT-Lymphocytes, RegulatoryTriple Negative Breast NeoplasmsTumor EscapeTumor MicroenvironmentImmune Checkpoint Inhibitors

Identifiers

PMID34607937
PMCPMC8578393
OpenAlexW3204276862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.