Evidence map›Paper›PMID 34607872›Full record

ArticleBMJ open2021

Ovarian Cancer Epidemiology, Healthcare Access and Disparities (ORCHiD): methodology for a population-based study of black, Hispanic and white patients with ovarian cancer.

Tomi Akinyemiju, April Deveaux, Lauren Wilson, Anjali Gupta, Ashwini Joshi, Malcolm Bevel, Chioma Omeogu, Onyinye Ohamadike, Bin Huang, Maria Pisu and 8 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  8. Psychosocial Stress Exposures and Advanced Disease at Ovarian Cancer Diagnosis.Cancer control : journal of the Moffitt Cancer Center
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Tomi AkinyemijuDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA tomi.akinyemiju@duke.edu.ORCID 0000-0002-1412-3234
April DeveauxDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-1185-7750
Lauren WilsonDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-5953-2293
Anjali GuptaDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Ashwini JoshiDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-9287-6370
Malcolm BevelDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-9907-0089
Chioma OmeoguDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Onyinye OhamadikeDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Bin HuangDepartment of Biostatistics and Kentucky Cancer Registry, University of Kentucky, Lexington, Kentucky, USA.
Maria PisuDivision of Preventive Medicine, The University of Alabama, Birmingham, Alabama, USA.
Margaret LiangDivision of Preventive Medicine, The University of Alabama, Birmingham, Alabama, USA.
Molly McFatrichDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Erin DaniellDepartment of Population Health Sciences, Duke University School of Medicine, Durham, North Carolina, USA.
Laura Jane FishDuke University School of Medicine, Duke Cancer Institute, Durham, North Carolina, USA.
Kevin WardGeorgia Cancer Registry, Emory University, Atlanta, Georgia, USA.
Maria SchymuraNew York State Cancer Registry, New York State Department of Health, Albany, New York, USA.
Andrew BerchuckDivision of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina, USA.
Arnold L PotoskyGeorgetown University Medical Center, Washington, District of Columbia, USA.
Duke University · USUniversity of Alabama · USEmory University · USGeorgetown University · USGynecologic Oncology Group · USNew York State Department of Health · USUniversity of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
Stress-related inflammation and racial disparities in ovarian cancerR37CA233777 · NCI · DUKE UNIVERSITY · PI AKINYEMIJU, TOMI F · 2019 to 2025
$4.2M
NCI NIH HHS P30 CA177558NCI NIH HHS R37 CA233777
6 · The paper itself

Abstract

introductionLess than 40% of patients with ovarian cancer (OC) in the USA receive stage-appropriate guideline-adherent surgery and chemotherapy. Black patients with cancer report greater depression, pain and fatigue than white patients. Lack of access to healthcare likely contributes to low treatment rates and racial differences in outcomes. The Ovarian Cancer Epidemiology, Healthcare Access and Disparities study aims to characterise healthcare access (HCA) across five specific dimensions-Availability, Affordability, Accessibility, Accommodation and Acceptability-among black, Hispanic and white patients with OC, evaluate the impact of HCA on quality of treatment, supportive care and survival, and explore biological mechanisms that may contribute to OC disparities. METHODS AND ANALYSIS: We will use the Surveillance Epidemiology and Ends Results dataset linked with Medicare claims data from 9744 patients with OC ages 65 years and older. We will recruit 1641 patients with OC (413 black, 299 Hispanic and 929 white) from cancer registries in nine US states. We will examine HCA dimensions in relation to three main outcomes: (1) receipt of quality, guideline adherent initial treatment and supportive care, (2) quality of life based on patient-reported outcomes and (3) survival. We will obtain saliva and vaginal microbiome samples to examine prognostic biomarkers. We will use hierarchical regression models to estimate the impact of HCA dimensions across patient, neighbourhood, provider and hospital levels, with random effects to account for clustering. Multilevel structural equation models will estimate the total, direct and indirect effects of race on treatment mediated through HCA dimensions. ETHICS AND DISSEMINATION: Result dissemination will occur through presentations at national meetings and in collaboration with collaborators, community partners and colleagues across othercancer centres. We will disclose findings to key stakeholders, including scientists, providers and community members. This study has been approved by the Duke Institutional Review Board (Pro00101872). Safety considerations include protection of patient privacy. All disseminated data will be deidentified and summarised.

Indexed as

Ovarian NeoplasmsQuality of LifeAgedFemaleHealthcare DisparitiesHealth Services AccessibilityHispanic or LatinoHumansMedicareUnited Statesepidemiologygynaecological oncologypublic healthquality in health carestatistics & research methods

Identifiers

PMID34607872
PMCPMC8491419
OpenAlexW3204754631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.