Evidence map›Paper›PMID 34607870›Full record

ArticleBMJ open2021

Understanding inequalities in COVID-19 outcomes following hospital admission for people with intellectual disability compared to the general population: a matched cohort study in the UK.

R Asaad Baksh, Sarah E Pape, James Smith, André Strydom

Abstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Article
  7. Use of anti-amyloid-β monoclonal antibodies in persons with Down syndrome Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  10. Role of Gender Equity and Disability Inclusion to Help Achieve the Larger Cause of Health for All and Attain SDG 2030 by India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2024
    Article
  11. Levelling up, with autism in mind.Journal of the Intensive Care Society · 2024
    Article
  12. Article
  13. Challenges and opportunities in adolescent intellectual disability care and rehabilitation.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Ableism in the intensive care unit.Intensive care medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

R Asaad BakshInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK asaad.baksh@kcl.ac.uk.ORCID 0000-0001-6596-2145
Sarah E PapeInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
James SmithSouth London and Maudsley NHS Foundation Trust, London, UK.
André StrydomInstitute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.

Funding

Medical Research Council MR/R024901/1Medical Research Council MR/S005145/1Medical Research Council MR/S011277/1
6 · The paper itself

Abstract

objectivesThis study explores the hospital journey of patients with intellectual disabilities (IDs) compared with the general population after admission for COVID-19 during the first wave of the pandemic (when demand on inpatient resources was high) to identify disparities in treatment and outcomes.

designMatched cohort study; an ID cohort of 506 patients were matched based on age, sex and ethnicity with a control group using a 1:3 ratio to compare outcomes from the International Severe Acute Respiratory and emerging Infections Consortium WHO Clinical Characterisation Protocol UK.

settingAdmissions for COVID-19 from UK hospitals; data on symptoms, severity, access to interventions, complications, mortality and length of stay were extracted.

interventionsNon-invasive respiratory support, intubation, tracheostomy, ventilation and admission to intensive care units (ICU).

resultsSubjective presenting symptoms such as loss of taste/smell were less frequently reported in ID patients, whereas indicators of more severe disease such as altered consciousness and seizures were more common. Controls had higher rates of cardiovascular risk factors, asthma, rheumatological disorder and smoking. ID patients were admitted with higher respiratory rates (median=22, range=10-48) and were more likely to require oxygen therapy (35.1% vs 28.9%). Despite this, ID patients were 37% (95% CI 13% to 57%) less likely to receive non-invasive respiratory support, 40% (95% CI 7% to 63%) less likely to receive intubation and 50% (95% CI 30% to 66%) less likely to be admitted to the ICU while in hospital. They had a 56% (95% CI 17% to 102%) increased risk of dying from COVID-19 after they were hospitalised and were dying 1.44 times faster (95% CI 1.13 to 1.84) compared with controls.

conclusionsThere have been significant disparities in healthcare between people with ID and the general population during the COVID-19 pandemic, which may have contributed to excess mortality in this group.

Indexed as

COVID-19Intellectual DisabilityCohort StudiesHospitalsHumansPandemicsSARS-CoV-2United Kingdomintensive & critical carepublic health

Identifiers

PMID34607870
PMCPMC8491000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.