Evidence map›Paper›PMID 34607836›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2021

Disease-Associated Risk Variants in

Danielle R Davari, Irene Orlow, Peter A Kanetsky, Li Luo, Sharon N Edmiston, Kathleen Conway, Eloise A Parrish, Honglin Hao, Klaus J Busam, Ajay Sharma and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 10 institutions in 5 countries.

Danielle R DavariDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-6738-9418
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-6234-6961
Peter A KanetskyDepartment of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0002-5567-9618
Li LuoDepartment of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, New Mexico.
Sharon N EdmistonDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-8273-446X
Kathleen ConwayDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Eloise A ParrishDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Honglin HaoDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Klaus J BusamDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ajay SharmaDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Anne KrickerSydney School of Public Health, The University of Sydney, Sydney, Australia.ORCID 0000-0002-7219-1227
Anne E CustDaffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, Australia.ORCID 0000-0002-5331-6370
Hoda Anton-CulverDepartment of Epidemiology, University of California, Irvine, Irvine, California.
Stephen B GruberCity of Hope National Medical Center, Duarte, California.ORCID 0000-0001-8656-7822
Richard P GallagherBC Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-2365-0391
Roberto ZanettiPiedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
Stefano RossoPiedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
Lidia SacchettoPiedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, Turin, Italy.
Terence DwyerMurdoch Children's Research Institute, Melbourne, Australia.ORCID 0000-0002-2091-7663
David W OllilaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-4129-6808
Colin B BeggDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0003-3772-1795
Marianne BerwickDepartment of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, New Mexico.ORCID 0000-0001-5062-2180
Nancy E Thomas
GEM Study Group
University of North Carolina at Chapel Hill · USMemorial Sloan Kettering Cancer Center · USPiedmont Reference Center for Epidemiology and Cancer Prevention · ITNew Mexico Cancer Center · USThe University of Sydney · AUCity Of Hope National Medical Center · USMoffitt Cancer Center · USThe University of Melbourne · AUUniversity of British Columbia · CAUniversity of California, Irvine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Sex Differences in Methylome Alterations and Mutational Burden in Early Stage MelanomaP01CA206980 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BERWICK, MARIANNE, THOMAS, NANCY E. · 2017 to 2022
$10.1M
Melanoma RAS/BRAF Mutation:Heterogeneity-Risk-PrognosisR01CA112243 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THOMAS, NANCY E. · 2005 to 2014
$5.4M
A MODEL FOR GENETIC SUSCEPTIBILITY: MELANOMAU01CA083180 · NCI · UNIVERSITY OF NEW MEXICO · PI BERWICK, MARIANNE · 1999 to 2003
$5.2M
Identification of Lethal Melanomas at the Time of DiagnosisR01CA233524 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTON-CULVER, HODA A, BEGG, COLIN B · 2020 to 2024
$4.5M
The Epidemiology of Immune Responses in Colorectal CancerR01CA197350 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GRUBER, STEPHEN B · 2015 to 2019
$3.2M
Solar Exposure and Melanoma SurvivalR01CA112524 · NCI · UNIVERSITY OF NEW MEXICO · PI BERWICK, MARIANNE · 2005 to 2009
$2.5M
Epidemiologic Parameters of Rare Cancer Risk FactorsR01CA098438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI BEGG, COLIN B · 2003 to 2005
$839k
Validation of the use of whole-genome amplified DNA in a population-based studyR03CA173806 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ORLOW, IRENE · 2013 to 2014
$170k
RAS/BRAF Melanoma Mutations: Precursors, Risk, PrognosisR03CA103089 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI THOMAS, NANCY E · 2003 to 2004
$146k
Mutational Analysis of Clonality in Multiple Primary MelanomaR03CA125829 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ORLOW, IRENE · 2006 to 2007
$128k
NCI NIH HHS P01 CA206980NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA098438NCI NIH HHS R01 CA112243NCI NIH HHS R01 CA112524NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA233524NCI NIH HHS R03 CA103089NCI NIH HHS R03 CA125829NCI NIH HHS R03 CA173806NCI NIH HHS U01 CA083180
6 · The paper itself

Abstract

backgroundGenome-wide association studies have reported that genetic variation at

methodsThe Genes, Environment, and Melanoma Study enrolled 3,285 European origin participants with incident invasive primary melanoma. For each of ten disease-associated SNPs at or near

resultsRs518394, rs10965215, and rs564398 passed false discovery and were each associated (

conclusionsIMPACT: Pathways related to

Indexed as

Cyclin-Dependent Kinase Inhibitor p15AgedCutaneous Malignant MelanomaFemaleGenome-Wide Association StudyGTP PhosphohydrolasesHumansLymphocytes, Tumor-InfiltratingMaleMelanomaMembrane ProteinsMiddle AgedMutationProto-Oncogene Proteins B-rafSkin NeoplasmsBRAF protein, humanCDKN2B protein, humanCyclin-Dependent Kinase Inhibitor p15GTP PhosphohydrolasesMembrane ProteinsNRAS protein, humanProto-Oncogene Proteins B-raf

Identifiers

PMID34607836
PMCPMC8643342
OpenAlexW3202784931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.