ReviewCold Spring Harbor perspectives in biology2022
Positional Memory in Vertebrate Regeneration: A Century's Insights from the Salamander Limb.
Review in Cold Spring Harbor perspectives in biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Tissue composition shapes differential skeletal integration strategies during axolotl limb regeneration.Nature communications · 2026Article
- Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration.Nature physics · 2026Article
- Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration.bioRxiv : the preprint server for biology · 2026Article
- tBid-Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Are axolotls resistant to cancer? Possible explanations.Molecular biology reports · 2026Review
- Glial cell states bias the regeneration of neuron types across the newt life cycle.bioRxiv : the preprint server for biology · 2026Article
- Digit regeneration in mice is stimulated by sequential treatment with FGF2 and BMP2.Nature communications · 2026Article
- The pathoanatomy of cancer: order in paradox.EBioMedicine · 2026Review
- Signal control during tissue regeneration in adult animals.Nature reviews. Molecular cell biology · 2026Review
- Dorsoventral-mediatedeLife · 2026Article
- Wnt/FGF20 signaling axis promotes migration of proximal blastema cell during tail regeneration of Gekko japonicus.Communications biology · 2025Article
- The planarian dorsal-ventral boundary regulates anterior-posterior axis growth and patterning.PLoS biology · 2025Article
- egal-1 and microtubules promote regeneration polarity in planarians.Development (Cambridge, England) · 2025Article
- Modeling proximalisation in axolotl limb regeneration.Scientific reports · 2025Article
- Unbiased profiling of multipotency landscapes reveals spatial modulators of clonal fate biases.bioRxiv : the preprint server for biology · 2025Article
- Article
- Review
- Hallmarks of regeneration.Cell stem cell · 2024Review
- The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Review
- High-resolution Cell Transplantation in Embryonic and Larval Zebrafish.Journal of visualized experiments : JoVE · 2024Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Salamanders, such as axolotls and newts, can regenerate complex tissues including entire limbs. But what mechanisms ensure that an amputated limb regenerates a limb, and not a tail or unpatterned tissue? An important concept in regeneration is positional memory-the notion that adult cells "remember" spatial identities assigned to them during embryogenesis (e.g., "head" or "hand") and use this information to restore the correct body parts after injury. Although positional memory is well documented at a phenomenological level, the underlying cellular and molecular bases are just beginning to be decoded. Herein, we review how major principles in positional memory were established in the salamander limb model, enabling the discovery of positional memory-encoding molecules, and advancing insights into their pattern-forming logic during regeneration. We explore findings in other amphibians, fish, reptiles, and mammals and speculate on conserved aspects of positional memory. We consider the possibility that manipulating positional memory in human cells could represent one route toward improved tissue repair or engineering of patterned tissues for therapeutic purposes.
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