Evidence map›Paper›PMID 34607587›Full record

ArticleBMC urology2021

Systemic and intrathecal baclofen produce bladder antinociception in rats.

Timothy J Ness, Alan Randich, Xin Su, Cary DeWitte, Keith Hildebrand

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Timothy J NessDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, BMR2-208, 901 19th Street South, Birmingham, AL, 35294, USA. tness@uabmc.edu.
Alan RandichDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, BMR2-208, 901 19th Street South, Birmingham, AL, 35294, USA.
Xin SuMedtronics, Inc., Minneapolis, MN, USA.
Cary DeWitteDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, BMR2-208, 901 19th Street South, Birmingham, AL, 35294, USA.
Keith HildebrandMedtronics, Inc., Minneapolis, MN, USA.
University of Alabama at Birmingham · USMedtronic (United States) · US

Funding

QUANTITATIVE STUDY OF URINARY BLADDER SENSORY PROCESSINGR01DK051413 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEBERRY, JENNIFER J, NESS, TIMOTHY J · 1997 to 2025
$5.4M
NIDDK NIH HHS DK51413NIDDK NIH HHS R01 DK051413
6 · The paper itself

Abstract

backgroundBaclofen, a clinically available GABA

methodsA series of experiments examined the effects of systemic and spinally administered baclofen on bladder nociception in female anesthetized rats. Models of bladder nociception included those which employed neonatal and adult bladder inflammation to produce bladder hypersensitivity.

resultsCumulative intraperitoneal dosing (1-8 mg/kg IP) and cumulative intrathecal dosing (10-160 ng IT) of baclofen led to dose-dependent inhibition of visceromotor responses (VMRs) to urinary bladder distension (UBD) in all tested models. There were no differences in the magnitude of the analgesic effects of baclofen as a function of inflammation versus no inflammation treatments. Hemodynamic (pressor) responses to UBD were similarly inhibited by IT baclofen as well as UBD-evoked excitatory responses of spinal dorsal horn neurons. The GABA

conclusionsThese data provide support for a clinical trial of baclofen as a non-opioid treatment of human bladder pain.

Indexed as

AnimalsBaclofenFemaleGABA-B Receptor AgonistsInjections, SpinalNociceptionRatsRats, Sprague-DawleyUrinary BladderBaclofenGABA-B Receptor AgonistsAntinociceptionGABAB receptorsInterstitial cystitis/bladder pain syndromeUrinary bladder

Identifiers

PMID34607587
PMCPMC8489106
OpenAlexW3161757626

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.