Evidence map›Paper›PMID 34607460›Full record

ArticlemBio2021

Foraging Signals Promote Swarming in Starving Pseudomonas aeruginosa.

Divakar Badal, Abhijith Vimal Jayarani, Mohammad Ameen Kollaran, Deep Prakash, Monisha P, Varsha Singh

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Functional organization and regulatory logic of theApplied and environmental microbiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Metagenomic shotgun sequencing reveals the enrichment ofComputational and structural biotechnology journal · 2024
    Article
  6. Article
  7. Article
  8. Antibacterial peptide Reg4 amelioratesMicrobiology spectrum · 2024
    Article
  9. Article
  10. Article
  11. Swarming ofBiophysics reviews · 2023
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Divakar Badal *Biosystems Science & Engineering, Indian Institute of Science, Bangalore, India.
Abhijith Vimal Jayarani *Department of Molecular Reproduction, Development & Genetics, Indian Institute of Science, Bangalore, India.
Mohammad Ameen Kollaran *Department of Molecular Reproduction, Development & Genetics, Indian Institute of Science, Bangalore, India.
Deep PrakashDepartment of Molecular Reproduction, Development & Genetics, Indian Institute of Science, Bangalore, India.
Monisha PDepartment of Molecular Reproduction, Development & Genetics, Indian Institute of Science, Bangalore, India.
Varsha SinghBiosystems Science & Engineering, Indian Institute of Science, Bangalore, India.ORCID 0000-0001-9391-5901
Indian Institute of Science Bangalore · IN

Funding

Wellcome Trust
6 · The paper itself

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa is known for exhibiting diverse forms of collective behaviors, like swarming motility and biofilm formation. Swarming in P. aeruginosa is a collective movement of the bacterial population over a semisolid surface, but specific swarming signals are not clear. We hypothesize that specific environmental signals induce swarming in P. aeruginosa. We show that under nutrient-limiting conditions, a low concentration of ethanol provides a strong ecological motivation for swarming in P. aeruginosa strain PA14. Ethanol serves as a signal and not a source of carbon under these conditions. Moreover, ethanol-driven swarming relies on the ability of the bacteria to metabolize ethanol to acetaldehyde using a periplasmic quinoprotein alcohol dehydrogenase, ExaA. We found that ErdR, an orphan response regulator linked to ethanol oxidation, is necessary for the transcriptional regulation of a cluster of 17 genes, including

Indexed as

Bacterial ProteinsCarbonEthanolFlagellaGene Expression Regulation, BacterialPseudomonas aeruginosaBacterial ProteinsCarbonEthanolCryptococcus neoformansethanol oxidationforaging signalPseudomonas aeruginosarhamnolipidstarvationswarming motility

Identifiers

PMID34607460
PMCPMC8546858
OpenAlexW3203576238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.