Evidence map›Paper›PMID 34607377›Full record

Trial reportEndoscopy2022

Artificial intelligence versus expert endoscopists for diagnosis of gastric cancer in patients who have undergone upper gastrointestinal endoscopy.

Ryota Niikura, Tomonori Aoki, Satoki Shichijo, Atsuo Yamada, Takuya Kawahara, Yusuke Kato, Yoshihiro Hirata, Yoku Hayakawa, Nobumi Suzuki, Masanori Ochi and 4 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07078136 (Multicenter Observational Study of a Multimodal AI Model Using EUS, White-Light Endoscopy, and Clinical Data for Diagnosis of Upper GI Mesenchymal Tumors and Risk Stratification of Gastric GISTs), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07078136 recruitingnot on this mapstarted 2025, after this paper: background citation

Multicenter Observational Study of a Multimodal AI Model Using EUS, White-Light Endoscopy, and Clinical Data for Diagnosis of Upper GI Mesenchymal Tumors and Risk Stratification of Gastric GISTs

TypeobservationalSponsorHuazhong University of Science and TechnologyRan2025 to 2026Enrolled130ConditionsSubmucosal Tumor, Gastrointestinal Stromal Tumor (GIST), Leiomyoma, SchwannomaArmsMultimodal AI Model, Expert Endoscopist Assessment
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Prevention of Gastric Cancer.Medicina (Kaunas, Lithuania) · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Artificial intelligence in gastrointestinal surgery: A systematic review.World journal of gastrointestinal surgery · 2025
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Artificial intelligence efficiently predicts gastric lesions,Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ryota NiikuraDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
Tomonori AokiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
Satoki ShichijoDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Atsuo YamadaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.ORCID 0000-0003-4314-7777
Takuya KawaharaClinical Research Promotion Center, The University of Tokyo Hospital, Tokyo, Japan.
Yusuke KatoAI Medical Service Inc., Tokyo, Japan.
Yoshihiro HirataDivision of Advanced Genome Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
Masanori OchiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.
Toshiaki HirasawaDepartment of Gastroenterology, Cancer Institute Hospital Ariake, Japanese Foundation for Cancer Research, Tokyo, Japan.
Tomohiro TadaAI Medical Service Inc., Tokyo, Japan.
Takashi KawaiGastroenterological Endoscopy, Tokyo Medical University, Tokyo, Japan.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo compare endoscopy gastric cancer images diagnosis rate between artificial intelligence (AI) and expert endoscopists. PATIENTS AND

methodsWe used the retrospective data of 500 patients, including 100 with gastric cancer, matched 1:1 to diagnosis by AI or expert endoscopists. We retrospectively evaluated the noninferiority (prespecified margin 5 %) of the per-patient rate of gastric cancer diagnosis by AI and compared the per-image rate of gastric cancer diagnosis.

resultsGastric cancer was diagnosed in 49 of 49 patients (100 %) in the AI group and 48 of 51 patients (94.12 %) in the expert endoscopist group (difference 5.88, 95 % confidence interval: -0.58 to 12.3). The per-image rate of gastric cancer diagnosis was higher in the AI group (99.87 %, 747 /748 images) than in the expert endoscopist group (88.17 %, 693 /786 images) (difference 11.7 %).

conclusionsNoninferiority of the rate of gastric cancer diagnosis by AI was demonstrated but superiority was not demonstrated.

Indexed as

Artificial IntelligenceStomach NeoplasmsEndoscopyEndoscopy, GastrointestinalHumansRetrospective Studies

Identifiers

PMID34607377
PMCPMC9329064

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.