ArticleCerebral cortex (New York, N.Y. : 1991)2022
Fine Particulate Air Pollution, Early Life Stress, and Their Interactive Effects on Adolescent Structural Brain Development: A Longitudinal Tensor-Based Morphometry Study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Regional brain volume prior to treatment is linked to outcome after cognitive rehabilitation in traumatic brain injury.NeuroImage. Clinical · 2022Trial
- Neighborhood opportunity, white matter, and cognition in a large pediatric neuroimaging study.Translational psychiatry · 2026Article
- Neighborhood air pollution is associated with attenuated neurocognitive maturation over early adolescence.Developmental cognitive neuroscience · 2026Article
- White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026Article
- Geographic Measures of Early Life-Course Social Exposome in the Evaluation of Structural Neuroanatomy: A Scoping Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Longitudinal associations between air pollution and adolescent gray matter development: Insights from the ABCD study.Environmental research · 2026Article
- The effect of the "exposome" on developmental brain health and cognitive outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Early Life Adversity and Disordered Eating: Cognitive and Neural Mechanisms.Behavioral sciences (Basel, Switzerland) · 2025Review
- Unraveling the impact of prenatal air pollution for neonatal brain maturation.Environment international · 2025Article
- Sources of outdoor air pollution exposure and child brain network development across the United States.bioRxiv : the preprint server for biology · 2025Article
- Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence.Biological psychiatry global open science · 2025Article
- Exposure to Fine Particulate Matter During Pregnancy Is Associated With Hippocampal Development in Offspring.Biological psychiatry global open science · 2025Article
- Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level.Environment international · 2025Article
- Development and validation of the cleanliness satisfaction scale (ESL-AK) in a sample of adults from the Province of San Román, Perú.BMC psychology · 2025Article
- Cumulative risk assessment as the pathway to public health protection for behavioral neurotoxicity.Neurotoxicology · 2025Review
- Functional Brain Connectivity Predictors of Prospective Substance Use Initiation and Their Environmental Correlates.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- The growing interdisciplinarity of developmental psychopathology: Implications for science and training.Development and psychopathology · 2024Article
- How does the macroenvironment influence brain and behaviour-a review of current status and future perspectives.Molecular psychiatry · 2024Review
- A Systematic Review of Air Pollution Exposure and Brain Structure and Function during Development.medRxiv : the preprint server for health sciences · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Air pollution is a major environmental threat to public health; we know little, however, about its effects on adolescent brain development. Exposure to air pollution co-occurs, and may interact, with social factors that also affect brain development, such as early life stress (ELS). Here, we show that severity of ELS and fine particulate air pollution (PM2.5) are associated with volumetric changes in distinct brain regions, but also uncover regions in which ELS moderates the effects of PM2.5. We interviewed adolescents about ELS events, used satellite-derived estimates of ambient PM2.5 concentrations, and conducted longitudinal tensor-based morphometry to assess regional changes in brain volume over an approximately 2-year period (N = 115, ages 9-13 years at Time 1). For adolescents who had experienced less severe ELS, PM2.5 was associated with volumetric changes across several gray and white matter regions. Fewer effects of PM2.5 were observed for adolescents who had experienced more severe ELS, although occasionally they were in the opposite direction. This pattern of results suggests that for many brain regions, moderate to severe ELS largely constrains the effects of PM2.5 on structural development. Further theory and research is needed on the joint effects of ELS and air pollution on the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.