ArticleNeuroImage2021
Quantification of volumetric morphometry and optical property in the cortex of human cerebellum at micrometer resolution.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain.bioRxiv : the preprint server for biology · 2026Article
- Myelinated fiber labeling and orientation mapping of the human brain with light-sheet fluorescence microscopy.NeuroImage · 2025Article
- The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells.Frontiers in physiology · 2025Review
- Three-dimensional fiber orientation mapping of ex vivo human brain at micrometer resolution.Npj imaging · 2025Article
- A multimodal submillimeter MRI atlas of the human cerebellum.Scientific reports · 2024Article
- Quantitative optical coherence microscopy of neuron morphology in human entorhinal cortex.Frontiers in neuroscience · 2023Article
- Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
The surface of the human cerebellar cortex is much more tightly folded than the cerebral cortex. Volumetric analysis of cerebellar morphometry in magnetic resonance imaging studies suffers from insufficient resolution, and therefore has had limited impact on disease assessment. Automatic serial polarization-sensitive optical coherence tomography (as-PSOCT) is an emerging technique that offers the advantages of microscopic resolution and volumetric reconstruction of large-scale samples. In this study, we reconstructed multiple cubic centimeters of ex vivo human cerebellum tissue using as-PSOCT. The morphometric and optical properties of the cerebellar cortex across five subjects were quantified. While the molecular and granular layers exhibited similar mean thickness in the five subjects, the thickness varied greatly in the granular layer within subjects. Layer-specific optical property remained homogenous within individual subjects but showed higher cross-subject variability than layer thickness. High-resolution volumetric morphometry and optical property maps of human cerebellar cortex revealed by as-PSOCT have great potential to advance our understanding of cerebellar function and diseases.
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Registered trials
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