Evidence map›Paper›PMID 34606833›Full record

ArticleThe Journal of allergy and clinical immunology2022

Association of mold levels in urban children's homes with difficult-to-control asthma.

Stephen Vesper, Larry Wymer, John Kroner, Jacqueline A Pongracic, Edward M Zoratti, Frédéric F Little, Robert A Wood, Carolyn M Kercsmar, Rebecca S Gruchalla, Michelle A Gill and 12 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Indoor and Outdoor Fungal Allergens and Impacts on Respiratory Allergic Disease.The journal of allergy and clinical immunology. In practice · 2025
    Review
  3. The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. New considerations of health disparities within allergy and immunology.The Journal of allergy and clinical immunology · 2023
    Review
  8. Severe Fungal Asthma: A Role for Biologics and Inhaled Antifungals.Journal of fungi (Basel, Switzerland) · 2023
    Article
  9. Leukocyte redistribution as immunological biomarker of corticosteroid resistance in severe asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 14 institutions in 1 country.

Stephen VesperUnited States Environmental Protection Agency, Center for Environmental Measurement and Modeling, Cincinnati, Ohio. Electronic address: vesper.stephen@epa.gov.
Larry WymerUnited States Environmental Protection Agency, Center for Environmental Measurement and Modeling, Cincinnati, Ohio.
John KronerCincinnati Children's Hospital, Cincinnati, Ohio.
Jacqueline A PongracicAnn and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Edward M ZorattiHenry Ford Health System, Detroit, Mich.
Frédéric F LittleBoston University School of Medicine, Boston, Mass.
Robert A WoodJohns Hopkins University School of Medicine, Baltimore, Md.
Carolyn M KercsmarCincinnati Children's Hospital, Cincinnati, Ohio.
Rebecca S GruchallaUniversity of Texas Southwestern Medical Center, Dallas, Tex.
Michelle A GillUniversity of Texas Southwestern Medical Center, Dallas, Tex.
Meyer KattanCollege of Physicians and Surgeons, Columbia University, New York, NY.
Stephen J TeachChildren's National Hospital, Washington, DC.
Shilpa PatelChildren's National Hospital, Washington, DC.
Christine C JohnsonHenry Ford Health System, Detroit, Mich.
Leonard B BacharierSt Louis Children's Hospital, St Louis, Mo.
James E GernUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Daniel J JacksonUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Steven M SigelmanNational Institute of Allergy and Infectious Diseases, Rockville, Md.
Alkis TogiasNational Institute of Allergy and Infectious Diseases, Rockville, Md.
Andrew H LiuNational Jewish Health, Aurora, Colo; Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colo.
William W BusseUniversity of Wisconsin School of Medicine and Public Health, Madison, Wis.
Gurjit K Khurana HersheyCincinnati Children's Hospital, Cincinnati, Ohio.
Cincinnati Children's Hospital Medical Center · USUniversity of Wisconsin–Madison · USChildren's National · USHenry Ford Health System · USNational Institute of Allergy and Infectious Diseases · USThe University of Texas Southwestern Medical Center · USBoston University · USChildren's Hospital Colorado · USColumbia University · USEnvironmental Protection Agency · USJohns Hopkins Medicine · USLurie Children's Hospital · USOhio Environmental Protection Agency · USSt. Louis Children's Hospital · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Childhood Asthma in Urban Settings Leadership Center Administrative Supplement for URECA Yr4UM1AI160040 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, DANIEL J JACKSON · 2021 to 2026
$41.1M
NIAID NIH HHS HHSN272200900052CNIAID NIH HHS HHSN272201000052INIAID NIH HHS UM1 AI114271NIAID NIH HHS UM1 AI160040
6 · The paper itself

Abstract

backgroundMold sensitization and exposure are associated with asthma severity, but the specific species that contribute to difficult-to-control (DTC) asthma are unknown.

objectiveWe sought to determine the association between overall and specific mold levels in the homes of urban children and DTC asthma.

methodsThe Asthma Phenotypes in the Inner-City study recruited participants, aged 6 to 17 years, from 8 US cities and classified each participant as having either DTC asthma or easy-to-control (ETC) asthma on the basis of treatment step level. Dust samples had been collected in each participant's home (n = 485), and any dust remaining (n = 265 samples), after other analyses, was frozen at -20

resultsFrozen-dust samples were available from 54% of homes of children with DTC (139 of 253) and ETC asthma (126 of 232). Only the average concentration of the mold Mucor was significantly (P < .001) greater in homes of children with DTC asthma. In homes with window air-conditioning units, the Mucor concentration contributed about a 22% increase (1.6 odds ratio; 95% CI, 1.2-2.2) in the ability to discriminate between cases of DTC and ETC asthma.

conclusionsMucor levels in the homes of urban youth were a predictor of DTC asthma, and these higher Mucor levels were more likely in homes with a window air-conditioner.

Indexed as

Air Pollution, IndoorAsthmaAdolescentAllergensDustFungiHousingHumansUrban PopulationAllergensDustair-conditionerAPICchildmoldMucorUS cities

Identifiers

PMID34606833
PMCPMC8975947
OpenAlexW3203911114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.