Evidence map›Paper›PMID 34606711›Full record

ArticleACS applied materials & interfaces2021

Protein-Based Films as Antifouling and Drug-Eluting Antimicrobial Coatings for Medical Implants.

Li-Sheng Wang, Sanjana Gopalakrishnan, David C Luther, Vincent M Rotello

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li-Sheng WangDepartment of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Sanjana GopalakrishnanDepartment of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
David C LutherDepartment of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID https://orcid.org/0000-0002-4697-8683
Vincent M RotelloDepartment of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID https://orcid.org/0000-0002-5184-5439

Funding

Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
NIAID NIH HHS R01 AI134770
6 · The paper itself

Abstract

Nosocomial infections, caused by bacterial contamination of medical devices and implants, are a serious healthcare concern. We demonstrate here, the use of fluorous-cured protein nanofilm coatings for generating antimicrobial surfaces. In this approach, bacteria-repelling films are created by heat-curing proteins in fluorous media. These films are then loaded with antibiotics, with release controlled via electrostatic interactions between therapeutic and protein film building blocks to provide bactericidal surfaces. This film fabrication process is additive-free, biocompatible, biodegradable, and can be used to provide antimicrobial coatings for both three-dimensional (2D) and 3D objects for use in indwelling devices.

Indexed as

AnimalsAnti-Bacterial AgentsBiofoulingCattleCoated Materials, BiocompatibleColistinDelayed-Action PreparationsDrug LiberationFluoresceinFluorescent DyesFluorocarbonsProstheses and ImplantsPseudomonas aeruginosaRhodamine 123Serum Albumin, BovineAnti-Bacterial AgentsCoated Materials, BiocompatibleColistinDelayed-Action PreparationsFluoresceinFluorescent DyesFluorocarbonsperfluorophenanthreneRhodamine 123Serum Albumin, Bovineantimicrobialbiomaterialscontrol drug releasefluorous mediaprotein film

Identifiers

PMID34606711
PMCPMC8556632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.