ArticleJournal of clinical laboratory analysis2021
Application of Sigma metrics in the quality control strategies of immunology and protein analytes.
Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Risk-based redesign of internal quality control procedures for emergency immunoassays in clinical laboratories: a multicenter study from China.Frontiers in medicine · 2026Article
- Enhancing Laboratory Quality: A Comprehensive Sigma Metric Analysis for Diverse Biochemical Parameters.EJIFCC · 2025Article
- The Application of Six Sigma to Assess the Analytical Performance of Plasma Proteins and Design a Risk-Based Statistical Quality Control Strategy: A Multicenter Study.Journal of clinical laboratory analysis · 2025Article
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- Application of Sigma metrics in the quality control strategies of immunology and protein analytes.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSix Sigma (6σ) is an efficient laboratory management method. We aimed to analyze the performance of immunology and protein analytes in terms of Six Sigma.
methodsAssays were evaluated for these 10 immunology and protein analytes: Immunoglobulin G (IgG), Immunoglobulin A (IgA), Immunoglobulin M (IgM), Complement 3 (C3), Complement 4 (C4), Prealbumin (PA), Rheumatoid factor (RF), Anti streptolysin O (ASO), C-reactive protein (CRP), and Cystatin C (Cys C). The Sigma values were evaluated based on bias, four different allowable total error (TEa) and coefficient of variation (CV) at QC materials levels 1 and 2 in 2020. Sigma Method Decision Charts were established. Improvement measures of analytes with poor performance were recommended according to the quality goal index (QGI), and appropriate quality control rules were given according to the Sigma values.
resultsWhile using the TEa
conclusionsThe laboratories should choose appropriate TEa goals and make judicious use of Sigma metrics as a quality improvement tool.
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