Evidence map›Paper›PMID 34606625›Full record

ArticleCancer2022

Subsequent malignant neoplasms in the Childhood Cancer Survivor Study: Occurrence of cancer types in which human papillomavirus is an established etiologic risk factor.

Tara O Henderson, Brynn W Fowler, Haley A Hamann, Paul C Nathan, Jillian Whitton, Wendy M Leisenring, Kevin C Oeffinger, Joseph P Neglia, Lucie M Turcotte, Michael A Arnold and 5 more

Abstract read
In one paragraph

Article in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Prophylactic HPV vaccination in HPV-related gynecologic cancers: European Society of Gynecological Oncology (ESGO) prevention committee opinion.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Tara O HendersonDepartment of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, Illinois.ORCID 0000-0001-9394-6206
Brynn W FowlerDepartment of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, Illinois.
Haley A HamannDepartment of Pediatrics, University of Chicago Comer Children's Hospital, Chicago, Illinois.
Paul C NathanHematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-0334-0871
Jillian WhittonFred Hutchinson Cancer Research Center, Seattle, Washington.
Wendy M LeisenringFred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-7405-0906
Kevin C OeffingerDuke Cancer Institute, Duke University, Durham, North Carolina.
Joseph P NegliaPediatric Hematology, Oncology, Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota.
Lucie M TurcottePediatric Hematology, Oncology, Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-4106-6172
Michael A ArnoldDepartment of Pathology, Children's Hospital of Colorado, University of Colorado, Denver, Colorado.
Miriam R ConcesDepartment of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio.
Rebecca M HowellRadiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee.
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee.
Kenneth A AlexanderPediatric Infectious Diseases, Nemours Children's Hospital, Orlando, Florida.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Michael A Dyer · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Treatment Modifications, Outcomes and Provider Decision Making in the Management of Subsequent Breast Cancers Among Survivors of Childhood CancerK08CA234232 · NCI · UNIVERSITY OF MINNESOTA · PI TURCOTTE, LUCIE MARIE · 2018 to 2021
$714k
NCI NIH HHS K08 CA234232NCI NIH HHS P30 CA021765NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV)-associated subsequent malignant neoplasms (SMN

methodsThe cumulative risk of SMN

resultsIn total, 46 survivors developed an SMN

conclusionsChildhood cancer survivors are at increased risk for SMN in sites susceptible to HPV-associated malignancies. Further research examining HPV in the etiology of SMN and the promotion of HPV vaccination and surveillance guidelines for SMN

Indexed as

AlphapapillomavirusCancer SurvivorsNeoplasmsNeoplasms, Second PrimaryVulvar NeoplasmsAdultChildFemaleHumansIncidenceMalePapillomaviridaeRiskRisk FactorsSEER Programcancer survivorsearly detection of cancerhuman papillomavirus (HPV)-associated malignancypediatric cancersubsequent malignant neoplasmssurvivorship care

Identifiers

PMID34606625
PMCPMC8738100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.