ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Cognitive Reserve Moderates the Efficiency of Prefrontal Cortex Activation Patterns of Gait in Older Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Do cognitive reserve proxies capture a common neural signature? A systematic review and meta-analysis of task-based fMRI studies.Psychoradiology · 2026Review
- Moderation between resting-state connectivity and brain amyloid levels on speed of cognitive and physical function in older adults: Evidence for network-based cognitive reserve.Aperture neuro · 2025Article
- Evaluation of Neural, Systemic and Extracerebral Activations During Active Walking Tasks in Older Adults Using fNIRS.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025Article
- Difference between Okinawan and Dutch older adults in prefrontal brain activation.Frontiers in aging neuroscience · 2025Article
- The contribution of cognitive reserve in explaining the dual-task walking performance in iNPH patients: comparison with other cognitive, functional, and socio-demographic variables.Aging clinical and experimental research · 2024Article
- Physical reserve and its underpinning functional neural networks moderate the relationship between white matter hyperintensity and postural balance in older adults with subcortical ischemic vascular cognitive impairment.Scientific reports · 2024Article
- Brain control of dual-task walking can be improved in aging and neurological disease.GeroScience · 2024Article
- The impact of music making on neural efficiency & dual-task walking performance in healthy older adults.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2024Article
- The prefrontal cortex hemodynamic responses to dual-task paradigms in older adults: A systematic review and meta-analysis.Heliyon · 2023Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive reserve (CR) protects against cognitive decline, but whether CR influences the efficiency of cortical control of gait has not been reported. The current study addressed this important gap in the literature. Specifically, we determined the role of CR in moderating the efficiency of functional near-infrared spectroscopy (fNIRS)-derived oxygenated hemoglobin (HbO2) in the prefrontal cortex (PFC) assessed during active walking. We hypothesized that higher CR would be associated with more efficient brain activation patterns.
methodsParticipants were 55 (mean age = 74.84; %female = 49.1) older adults who underwent the combined walking/fNIRS protocol and had magnetic resonance imaging data. We used an established dual-task walking paradigm that consisted of 3 task conditions: single-task walk (STW), single-task alpha (STA, cognitive task), and dual-task walk (DTW). Using the residual approach, CR was derived from a word-reading test score by removing variance accounted for by sociodemographic variables, tests of current cognitive functions, and a measure of structural brain integrity.
resultsCR moderated the change in fNIRS-derived HbO2 in the PFC across tasks. Higher CR was associated with smaller increases in fNIRS-derived HbO2 from the single tasks to dual-task walking (CR × DTW compared with STW: estimate = 0.183; p < .001; CR × DTW compared with STA: estimate = 0.257; p < .001). The moderation effect of CR remained significant when adjusting for multiple covariates and concurrent moderation effects of measures of gait performance, current cognitive functions, and structural integrity of the brain.
conclusionThe current study provided first evidence that higher CR was associated with better neural efficiency of walking in older adults.
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