Evidence map›Paper›PMID 34606554›Full record

ArticleJournal of materials chemistry. B2021

ROS-sensitive micelles for controlled delivery of antibiotics to combat intracellular

Jing Qiao, Shuolin Cui, May P Xiong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Jing QiaoInstitute of Advanced Materials, School of Chemistry and Chemical Engineering, and, Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing, 211189, China. mpxiong@uga.edu.ORCID 0000-0002-1263-986X
Shuolin CuiDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, 30602-2352, USA.ORCID 0000-0002-2774-3969
May P XiongDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA, 30602-2352, USA.ORCID 0000-0002-0472-2815
University of Georgia · US

Funding

LipoGels for Chelation of Transfusional Iron-OverloadR01DK099596 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI XIONG, M PANG · 2013 to 2017
$1.5M
NIDDK NIH HHS R01 DK099596
6 · The paper itself

Abstract

Bacteria can evade the immune system once they are engulfed by phagocytic host cells. This protects them against the bactericidal action of antibiotics and allows the infection to remain latent or to recur. Reactive oxygen species (ROS)-related stress has been implicated in various pathological conditions such as inflammatory diseases involving infections of host cells and can serve as a useful trigger for intracellular controlled drug delivery. We herein report on a fluorescent ROS-sensitive intracellular antibiotic delivery nanoparticle for encapsulation of rifampin (RIF) based on the principles of Förster Resonance Energy Transfer (FRET) that is capable of ratiometrically sensing H

Indexed as

Drug Delivery SystemsAnti-Bacterial AgentsFluorescent DyesHydrophobic and Hydrophilic InteractionsMicellesMicrobial Sensitivity TestsMolecular StructureParticle SizeReactive Oxygen SpeciesStaphylococcal InfectionsStaphylococcus aureusSurface PropertiesAnti-Bacterial AgentsFluorescent DyesMicellesReactive Oxygen Species

Identifiers

PMID34606554
PMCPMC8585726
OpenAlexW3197323435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.