Evidence map›Paper›PMID 34606456›Full record

ArticleIEEE transactions on visualization and computer graphics2022

Scope2Screen: Focus+Context Techniques for Pathology Tumor Assessment in Multivariate Image Data.

Jared Jessup, Robert Krueger, Simon Warchol, John Hoffer, Jeremy Muhlich, Cecily C Ritch, Giorgio Gaglia, Shannon Coy, Yu-An Chen, Jia-Ren Lin and 3 more

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on visualization and computer graphics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. SEAL: Spatially-resolved Embedding Analysis with Linked Imaging Data.IEEE transactions on visualization and computer graphics · 2026
    Article
  4. Review
  5. SEAL : Spatially-resolved Embedding Analysis with Linked Imaging Data.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Cell2Cell: Explorative Cell Interaction Analysis in Multi-Volumetric Tissue Data.IEEE transactions on visualization and computer graphics · 2025
    Article
  8. Aardvark: Composite Visualizations of Trees, Time-Series, and Images.IEEE transactions on visualization and computer graphics · 2025
    Article
  9. psudo: Exploring Multi-Channel Biomedical Image Data with Spatially and Perceptually Optimized Pseudocoloring.Computer graphics forum : journal of the European Association for Computer Graphics · 2024
    Article
  10. Residency Octree: A Hybrid Approach for Scalable Web-Based Multi-Volume Rendering.IEEE transactions on visualization and computer graphics · 2024
    Article
  11. DASS Good: Explainable Data Mining of Spatial Cohort Data.Computer graphics forum : journal of the European Association for Computer Graphics · 2023
    Article
  12. Visinity: Visual Spatial Neighborhood Analysis for Multiplexed Tissue Imaging Data.IEEE transactions on visualization and computer graphics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jared Jessup
Robert Krueger
Simon Warchol
John Hoffer
Jeremy Muhlich
Cecily C Ritch
Giorgio Gaglia
Shannon Coy
Yu-An Chen
Jia-Ren Lin
Sandro Santagata
Peter K Sorger
Hanspeter Pfister
Harvard University · USBrigham and Women's Hospital · USCenter for Systems Biology · US

Funding

TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Systems Pharmacology of Therapeutic and Adverse Responses to ImmuneCheckpoint and Small Molecule DrugsU54CA225088 · NCI · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2018 to 2022
$10.8M
Omic and Multidimensional Spatial Atlas of Metastatic Breast CancerU2CCA233280 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOECKS, JEREMY · 2018 to 2023
$9.7M
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)U2CCA233262 · NCI · HARVARD MEDICAL SCHOOL · PI SORGER, PETER KARL · 2018 to 2023
$8.7M
NCI NIH HHS U2C CA233262NCI NIH HHS U2C CA233280NCI NIH HHS U54 CA225088NIGMS NIH HHS T32 GM007748
6 · The paper itself

Abstract

Inspection of tissues using a light microscope is the primary method of diagnosing many diseases, notably cancer. Highly multiplexed tissue imaging builds on this foundation, enabling the collection of up to 60 channels of molecular information plus cell and tissue morphology using antibody staining. This provides unique insight into disease biology and promises to help with the design of patient-specific therapies. However, a substantial gap remains with respect to visualizing the resulting multivariate image data and effectively supporting pathology workflows in digital environments on screen. We, therefore, developed Scope2Screen, a scalable software system for focus+context exploration and annotation of whole-slide, high-plex, tissue images. Our approach scales to analyzing 100GB images of 10

Indexed as

Computer GraphicsNeoplasmsHumansMicroscopySoftware

Identifiers

PMID34606456
PMCPMC8805697
OpenAlexW3204857299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.