ArticleInfection and immunity2022
Secretory Proteases of the Human Skin Microbiome.
Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Aspartyl protease MfSAP2 is a key virulence factor in mycelial form of skin fungi Malassezia furfur.The Biochemical journal · 2025Article
- Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins.Infection and immunity · 2025Article
- The skin microbiome on healthy and inflammatory altered canine skin determined by next generation sequencing.Frontiers in microbiology · 2025Article
- Host-Pathogen Interaction and Resistance Mechanisms in Dermatophytes.Pathogens (Basel, Switzerland) · 2024Review
- Spatiotemporal proteolytic susceptibility of allergens: positive or negative effects on the allergic sensitization?Frontiers in allergy · 2024Review
- Article
- Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection.PLoS pathogens · 2023Article
- Transcriptional Interplay betweenJournal of microbiology and biotechnology · 2023Article
- Stabilization of Acne Vulgaris-Associated Microbial Dysbiosis with 2% Supramolecular Salicylic Acid.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The human pathobiontProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Expression ofJID innovations : skin science from molecules to population health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human skin is our outermost layer and serves as a protective barrier against external insults. Advances in next-generation sequencing have enabled the discoveries of a rich and diverse community of microbes-bacteria, fungi, and viruses that are residents of this surface. The genomes of these microbes also revealed the presence of many secretory enzymes. In particular, proteases which are hydrolytic enzymes capable of protein cleavage and degradation are of special interest in the skin environment, which is enriched in proteins and lipids. In this minireview, we will focus on the roles of these skin-relevant microbial secreted proteases, in terms of both their widely studied roles as pathogenic agents in tissue invasion and host immune inactivation and their recently discovered roles in intermicrobial interactions and modulation of virulence factors. From these studies, it has become apparent that while microbial proteases are capable of a wide range of functions, their expression is tightly regulated and highly responsive to the environments the microbes are in. With the introduction of new biochemical and bioinformatics tools to study protease functions, it will be important to understand the roles played by skin microbial secretory proteases in cutaneous health, especially the less studied commensal microbes with an emphasis on contextual relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.