Evidence map›Paper›PMID 34606334›Full record

ArticleAntimicrobial agents and chemotherapy2022

Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance.

Lucie Paloque, Romain Coppée, Barbara H Stokes, Nina F Gnädig, Karamoko Niaré, Jean-Michel Augereau, David A Fidock, Jérôme Clain, Françoise Benoit-Vical

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Mapping the prevalence of molecular markers ofmedRxiv : the preprint server for health sciences · 2025
    Article
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  6. Genomic Surveillance ofPathogens (Basel, Switzerland) · 2025
    Article
  7. A NovelmedRxiv : the preprint server for health sciences · 2025
    Article
  8. Tracking Drug Resistance inInternational journal of molecular sciences · 2025
    Article
  9. Artemisinin pressure in field isolates can select highly resistantAntimicrobial agents and chemotherapy · 2025
    Article
  10. Article
  11. Article
  12. Applications of CRISPR in Parasitology.Current pharmaceutical biotechnology · 2025
    Review
  13. Artemisinin-resistant malaria.Clinical microbiology reviews · 2024
    Review
  14. Article
  15. Review
  16. Molecular Surveillance of Artemisinin-ResistantInternational journal of environmental research and public health · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Lucie Paloque *LCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0003-0359-3959
Romain Coppée *Université de Paris, MERIT, IRD, Paris, France.
Barbara H StokesDepartment of Microbiology and Immunology, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.
Nina F GnädigDepartment of Microbiology and Immunology, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.
Karamoko NiaréMalaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
Jean-Michel AugereauLCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.
David A FidockDepartment of Microbiology and Immunology, Department of Medicine, Columbia Universitygrid.239585.0grid.21729.3f Irving Medical Center, New York, New York, USA.
Jérôme ClainUniversité de Paris, MERIT, IRD, Paris, France.
Françoise Benoit-VicalLCC-CNRS, Laboratoire de Chimie de Coordination, Université de Toulouse, CNRS, Toulouse, France.ORCID 0000-0002-9468-4823
Centre National de la Recherche Scientifique · FRColumbia University Irving Medical Center · USUniversité Claude Bernard Lyon 1 · FRUniversité des Sciences, des Techniques et des Technologies de Bamako · MLUniversité Paris Cité · FR

Funding

Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
NIAID NIH HHS R01 AI109023NIAID NIH HHS T32 AI106711
6 · The paper itself

Abstract

Partial artemisinin resistance, defined in patients as a delayed parasite clearance following artemisinin-based treatment, is conferred by non-synonymous mutations in the Kelch beta-propeller domain of the Plasmodium falciparum

Indexed as

AntimalarialsArtemisininsBTB-POZ DomainProtozoan ProteinsDrug ResistanceMutationPlasmodium falciparumAntimalarialsArtemisininsProtozoan Proteinsartemisinin resistanceBTB/POZ domainK13 mutationmalaria

Identifiers

PMID34606334
PMCPMC8765297
OpenAlexW3202967872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.