Evidence map›Paper›PMID 34606284›Full record

ArticleJournal of proteome research2021

Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences.

Renze Ma, Julia H R Johnson, Yun Tang, Michael C Fitzgerald

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CJournal of proteome research · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Renze MaDepartment of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708-0346, United States.
Julia H R JohnsonDepartment of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708-0346, United States.
Yun TangDepartment of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708-0346, United States.
Michael C FitzgeraldDepartment of Chemistry, Duke University, Box 90346, Durham, North Carolina 27708-0346, United States.ORCID 0000-0002-6719-4722
Duke University · US

Funding

Global Measurements of Protein Folding Stability for Characterization of Aging and DiseaseR01GM134716 · NIGMS · DUKE UNIVERSITY · PI FITZGERALD, MICHAEL C · 2019 to 2022
$1.2M
NIGMS NIH HHS R01 GM134716
6 · The paper itself

Abstract

Here, we utilize the stability of proteins from rates of oxidation (SPROX) technique, to profile the thermodynamic stabilities of proteins in brain tissue cell lysates from Huα-Syn(A53T) transgenic mice at three time points including at 1 month (

Indexed as

SynucleinopathiesAgingalpha-SynucleinAnimalsBrainDisease Models, AnimalMiceMice, TransgenicProtein Stabilityalpha-Synucleinchemical denaturationmass spectrometryprotein foldingSPROX

Identifiers

PMID34606284
PMCPMC9288659
OpenAlexW3204058313

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.