Evidence map›Paper›PMID 34606005›Full record

ArticleJournal of clinical monitoring and computing2022

Predicting hypoglycemia in critically Ill patients using machine learning and electronic health records.

Sreekar Mantena, Aldo Robles Arévalo, Jason H Maley, Susana M da Silva Vieira, Roselyn Mateo-Collado, João M da Costa Sousa, Leo Anthony Celi

Abstract readMulticenter Study
In one paragraph

Article in Journal of clinical monitoring and computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Hospital Diabetes Meeting 2022.Journal of diabetes science and technology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sreekar MantenaHarvard University, Cambridge, MA, USA.
Aldo Robles ArévaloIDMEC, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Jason H MaleyBeth Israel Deaconess Medical Center, Boston, MA, USA.
Susana M da Silva VieiraIDMEC, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Roselyn Mateo-ColladoRush University Medical Center, Chicago, IL, USA.
João M da Costa SousaIDMEC, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Leo Anthony CeliBeth Israel Deaconess Medical Center, Boston, MA, USA. lceli@mit.edu.

Funding

Critical Care Informatics: Ethical considerations around the use and sharing of health-related dataR01EB017205 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CELI, LEO ANTHONY G, MARK, ROGER GREENWOOD · 2014 to 2021
$3.8M
European Regional Development Fund LISBOA-01-0145-FEDER-031474Fundação da Ciência e da Tecnologia (FCT) PhD Fellowship PD/BD/114107/2015Instituto Superior Técnico Project Grant UIDB/50022/2020NIBIB NIH HHS R01 E017215NIBIB NIH HHS R01 EB017205Programa Operacional Regional de Lisboa PTDC/EME-SIS/31474/2017
6 · The paper itself

Abstract

Hypoglycemia is a common occurrence in critically ill patients and is associated with significant mortality and morbidity. We developed a machine learning model to predict hypoglycemia by using a multicenter intensive care unit (ICU) electronic health record dataset. Machine learning algorithms were trained and tested on patient data from the publicly available eICU Collaborative Research Database. Forty-four features including patient demographics, laboratory test results, medications, and vitals sign recordings were considered. The outcome of interest was the occurrence of a hypoglycemic event (blood glucose < 72 mg/dL) during a patient's ICU stay. Machine learning models used data prior to the second hour of the ICU stay to predict hypoglycemic outcome. Data from 61,575 patients who underwent 82,479 admissions at 199 hospitals were considered in the study. The best-performing predictive model was the eXtreme gradient boosting model (XGBoost), which achieved an area under the received operating curve (AUROC) of 0.85, a sensitivity of 0.76, and a specificity of 0.76. The machine learning model developed has strong discrimination and calibration for the prediction of hypoglycemia in ICU patients. Prospective trials of these models are required to evaluate their clinical utility in averting hypoglycemia within critically ill patient populations.

Indexed as

Critical IllnessHypoglycemiaBlood GlucoseElectronic Health RecordsHumansHypoglycemic AgentsIntensive Care UnitsMachine LearningProspective StudiesRetrospective StudiesBlood GlucoseHypoglycemic AgentsBlood glucoseCritical careHypoglycemiaIntensive care unitMachine learning

Identifiers

PMID34606005
PMCPMC9152921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.