Evidence map›Paper›PMID 34605960›Full record

ReviewEuropean child & adolescent psychiatry2022

European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part IV: deep brain stimulation.

Natalia Szejko, Yulia Worbe, Andreas Hartmann, Veerle Visser-Vandewalle, Linda Ackermans, Christos Ganos, Mauro Porta, Albert F G Leentjens, Jan-Hinnerk Mehrkens, Daniel Huys and 8 more

Abstract readReview
In one paragraph

Review in European child & adolescent psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Challenges in the treatment of Tourette syndrome in the Philippines.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Deep brain stimulation for Tourette's syndrome.The Cochrane database of systematic reviews · 2024
    Article
  13. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Updated European guidelines for Tourette syndrome: and now use them!European child & adolescent psychiatry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Natalia SzejkoDepartment of Neurology, Medical University of Warsaw, Banacha 1a, 02-091, Warsaw, Poland. natalia.szejko@wum.edu.pl.ORCID http://orcid.org/0000-0001-6160-9221
Yulia WorbeDepartment on Neurophysiology, Saint Antoine Hospital, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0001-5903-9370
Andreas HartmannDepartment of Neurosurgery, Pitié-Salpetriere Hospital, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0002-0335-984X
Veerle Visser-VandewalleDepartment of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-5274-7929
Linda AckermansDepartment of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Christos GanosDepartment of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-8077-8530
Mauro PortaDepartment of Neurosurgery and Neurology, IRCCS Instituto Ortopedico Galeazzi, Milan, Italy.
Albert F G LeentjensDepartment of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0002-7901-571X
Jan-Hinnerk MehrkensDepartment of Neurosurgery, Ludwig-Maximilians-University of Munich, Munich, Germany.
Daniel HuysDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-9124-4128
Juan Carlos BaldermannDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-5851-9268
Jens KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-3258-930X
Carine KarachiNational Reference Center for Tourette Disorder, Pitié Salpetiere Hospital, Paris, France.
Cécile DelormeDepartment of Neurosurgery, Pitié-Salpetriere Hospital, Sorbonne Université, Paris, France.ORCID http://orcid.org/0000-0002-5838-9077
Thomas FoltynieDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.ORCID http://orcid.org/0000-0003-0752-1813
Andrea E CavannaInstitute of Clinical Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-0925-1255
Danielle CathDepartment of Specialist Trainings, GGZ Drenthe Mental Health Institution, Assen, The Netherlands.ORCID http://orcid.org/0000-0001-9539-4118
Kirsten Müller-VahlClinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.ORCID http://orcid.org/0000-0002-7181-7419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2011 the European Society for the Study of Tourette Syndrome (ESSTS) published its first European clinical guidelines for the treatment of Tourette Syndrome (TS) with part IV on deep brain stimulation (DBS). Here, we present a revised version of these guidelines with updated recommendations based on the current literature covering the last decade as well as a survey among ESSTS experts. Currently, data from the International Tourette DBS Registry and Database, two meta-analyses, and eight randomized controlled trials (RCTs) are available. Interpretation of outcomes is limited by small sample sizes and short follow-up periods. Compared to open uncontrolled case studies, RCTs report less favorable outcomes with conflicting results. This could be related to several different aspects including methodological issues, but also substantial placebo effects. These guidelines, therefore, not only present currently available data from open and controlled studies, but also include expert knowledge. Although the overall database has increased in size since 2011, definite conclusions regarding the efficacy and tolerability of DBS in TS are still open to debate. Therefore, we continue to consider DBS for TS as an experimental treatment that should be used only in carefully selected, severely affected and otherwise treatment-resistant patients.

Indexed as

Deep Brain StimulationTic DisordersTourette SyndromeDatabases, FactualHumansRegistriesDeep brain stimulationEuropean Society for the Study of Tourette Syndrome (ESSTS)GuidelinesTicsTourette syndromeTreatment

Identifiers

PMID34605960
PMCPMC8940783

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.