Evidence map›Paper›PMID 34605957›Full record

ArticleSkeletal radiology2022

Percutaneous CT-guided corticosteroid injection for the treatment of osseous Langerhans cell histocytosis: a three institution retrospective analysis.

Connie Y Chang, Julio Brandao Guimares, Gabby Joseph, Marcelo de Toledo Petrilli, Santiago Lozano-Calderon, Miriam A Bredella, Thomas M Link

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Skeletal radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Rapid response of aggressive cranial Langerhans cell histiocytosis to combined intralesional and perilesional triamcinolone injection: a case report with video.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Connie Y ChangDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Yawkey 6E, Boston, MA, 02114, USA. cychang@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-1304-1576
Julio Brandao GuimaresDiagnostic Imaging Center, Pediatric Oncology Institute, Grupo de Apoio Ao Adolescente E À Criança Com Câncer (GRAACC), Sao Paulo, Brazil.
Gabby JosephDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Marcelo de Toledo PetrilliDepartment of Orthopedic Surgery, Pediatric Oncology Institute, Grupo de Apoio Ao Adolescente E À Criança Com Câncer (GRAACC), Sao Paulo, Brazil.
Santiago Lozano-CalderonDepartment of Orthopedics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Miriam A BredellaDivision of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street Yawkey 6E, Boston, MA, 02114, USA.
Thomas M LinkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Harvard University · USSupport group for adolescents and children with cancer · BRUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to evaluate the safety and effectiveness of CT-guided corticosteroid injection for the treatment of osseous Langerhans cell histiocytosis (LCH) in a multi-institutional study. MATERIALS AND

methodsThis IRB-approved study included patients from three institutions. We retrospectively reviewed clinical, procedural, and imaging data for corticosteroid injections performed to treat osseous LCH. Location of the lesion, lesion maximum dimension and volume, corticosteroid type and dose, and time interval between injection and change in lesion size/volume and symptoms were recorded. Generalized estimating equations (accounting for multiple lesions per subject) were used to evaluate the association between predictors (dose, maximum lesion dimension, and lesion volume) and outcomes (time to partial and complete radiographic resolution, and time to pain control). This analysis was adjusted by anatomic site.

resultsForty corticosteroid injections were performed in 36 patients (20 (56%) females, and 16 (44%) males, ages 12 ± 11 (2-57) years). Mean lesion maximum dimension was 3.2 ± 1.7 cm, and volume was 10 ± 17 cm

conclusionCT-guided corticosteroid injection is a safe and effective treatment for LCH. Pain resolution was achieved in all patients and imaging did not show progressive disease in any of the patients.

Indexed as

Histiocytosis, Langerhans-CellLangerhans CellsAdolescentAdrenal Cortex HormonesAdultChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTomography, X-Ray ComputedTreatment OutcomeYoung AdultAdrenal Cortex HormonesCorticosteroidCT-guided injectionLangerhans cell histiocytosis

Identifiers

PMID34605957
OpenAlexW3203020665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.