Evidence map›Paper›PMID 34605955›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Relationship between the vessel density around the optic nerve head and visual field deterioration in eyes with retinitis pigmentosa.

Kosuke Nakajima, Tatsuya Inoue, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono, Asako Ogawa, Yohei Hashimoto, Keiko Azuma, Ryo Terao, Ryo Asaoka and 1 more

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kosuke NakajimaDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Tatsuya InoueDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan. inouet-tky@umin.ac.jp.
Maiko Maruyama-InoueDepartment of Ophthalmology and Micro-Technology, Yokohama City University School of Medicine, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
Yasuo YanagiDepartment of Ophthalmology and Micro-Technology, Yokohama City University School of Medicine, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
Kazuaki KadonosonoDepartment of Ophthalmology and Micro-Technology, Yokohama City University School of Medicine, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa, 232-0024, Japan.
Asako OgawaDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Yohei HashimotoDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Keiko AzumaDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Ryo TeraoDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Ryo AsaokaDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Ryo ObataDepartment of Ophthalmology, The University of Tokyo, Tokyo, Japan.
The University of Tokyo · JPYokohama City University · JPSeirei Christopher University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze the vessel density around the optic nerve head (ONH) by optical coherence tomography angiography (OCTA) in patients with retinitis pigmentosa (RP), and to evaluate its correlation with visual functions.

methodsThirty-eight eyes with RP with visual field constriction within the central 10° were enrolled. The mean (± SD) age of the patients was 43.7 ± 15.1 years. In addition to visual acuity (VA) measurements and visual field tests (Humphrey Field Analyzer 10-2 test), we also measured the vessel density at the macula by OCTA (superficial and deep vessel density: sVD(m) and dVD(m)) and in multiple layers around the ONH (vessel density in the radial peripapillary capillary [RPC] layer and in the nerve head [NH] layer: VDrpc and VDnh). The vessel density was calculated by binarizing the OCTA images. The associations between the logMAR VA and mean deviation (MD) values and the variables of central retinal thickness (CRT), sVD(m), dVD(m), VDrpc, VDnh, and also the size of the foveal avascular zone were investigated.

resultsThe mean logMAR VA was 0.16 ± 0.34 and the MD value was - 17.2 ± 10.3 dB; the MD value was significantly related to the logMAR VA (p = 0.0028). Multivariate analysis with AICc model selection suggested only dVD(m) was associated with logMAR VA. On the other hand, the optimal model for the MD value included the CRT, dVD(m), and VDnh.

conclusionThe vessel density in the deep layer around the ONH was significantly associated with the visual field deterioration in patients with RP.

Indexed as

Optic DiskRetinitis PigmentosaAdultFluorescein AngiographyHumansMiddle AgedRetinal VesselsTomography, Optical CoherenceVisual FieldsOptical coherence tomography angiographyOptic discOptic nerve headRetinitis pigmentosa

Identifiers

PMID34605955
OpenAlexW3204379515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.