ArticleJournal of the American Chemical Society2021
RNA-Inspired and Accelerated Degradation of Polylactide in Seawater.
Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Precise Structural Design for Chemically Recyclable Polymers.Precision chemistry · 2026Review
- Precision Oligomeric Building Blocks toward Chemically Recyclable Polyolefin-like Materials.Precision chemistry · 2026Review
- Conformational preorganization of neighbouring groups modulates and expedites polymer self-deconstruction.Nature chemistry · 2026Article
- Biological and Physicochemical Characterization of Biodegradable Aliphatic Polyesters with Copper Deposited by Magnetron Sputtering.Materials (Basel, Switzerland) · 2025Article
- Mechanically-robust and humidity-tunable self-destructive polymers enabled by hydrogen-bond nanoconfinement.Nature communications · 2025Article
- Rubber-like and Antifouling Poly(trimethylene carbonate-ethylphosphonate) Copolymers with Tunable Hydrolysis.ACS applied materials & interfaces · 2025Article
- Effect of Fiber Cross-Sectional and Surface Properties on the Degradation of Biobased Polymers.Polymers · 2024Article
- Glycerol-derived organic carbonates: environmentally friendly plasticizers for PLA.RSC advances · 2024Article
- Real-timeCommunications chemistry · 2023Article
- Polyethylene-Like Blends Amenable to Abiotic Hydrolytic Degradation.ACS sustainable chemistry & engineering · 2023Article
- Article
- RNA-inspired intramolecular transesterification accelerates the hydrolysis of polyethylene-like polyphosphoesters.Chemical science · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine plastic pollution is a worldwide challenge making advances in the field of biodegradable polymer materials necessary. Polylactide (PLA) is a promising biodegradable polymer used in various applications; however, it has a very slow seawater degradability. Herein, we present the first library of PLA derivatives with incorporated "breaking points" to vary the speed of degradation in artificial seawater from years to weeks. Inspired by the fast hydrolysis of ribonucleic acid (RNA) by intramolecular transesterification, we installed phosphoester breaking points with similar hydroxyethoxy side groups into the PLA backbone to accelerate chain scission. Sequence-controlled anionic ring-opening copolymerization of lactide and a cyclic phosphate allowed PLA to be prepared with controlled distances of the breaking points along the backbone. This general concept could be translated to other slowly degrading polymers and thereby be able to prevent additional marine pollution in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.