SynthesisThoracic cancer2021
Diagnostic efficacy of sentinel lymph node in breast cancer under percutaneous contrast-enhanced ultrasound: An updated meta-analysis.
Synthesis in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Prediction of sentinel lymph node status in patients with early breast cancer using breast imaging as an alternative to surgical staging-a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Diagnostic efficacy of sentinel lymph node in breast cancer under percutaneous contrast-enhanced ultrasound: An updated meta-analysis.Thoracic cancer · 2021Pooled it
- Preoperative contrast-enhanced ultrasound combined with intra-lymph node methylene blue injection for sentinel lymph node identification: a minimally invasive sentinel lymph node biopsy tracing approach.European radiology · 2026Trial
- Exploring the Evolution of Breast Cancer Imaging: A Review of Conventional and Emerging Modalities.Cureus · 2025Review
- Correlation between ultrasound measurements and the expression of Her-2 and CD147 in breast cancer.American journal of translational research · 2025Article
- Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2023Article
- Sentinel Lymph Node Detection in Breast Cancer: An Innovative Technique.Diagnostics (Basel, Switzerland) · 2023Article
- Anatomy Versus Physiology: Is Breast Lymphatic Drainage to the Internal Thoracic (Internal Mammary) Lymphatic System Clinically Relevant?Journal of breast cancer · 2023Article
- [Contrast-enhanced ultrasonography with intra-glandular contrast injection can improve the diagnostic accuracy of central compartment lymph node metastasis of thyroid cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Sentinel Lymph Node Identification in Patients With Breast Cancer Using Lymphosonography.Ultrasound in medicine & biology · 2023Article
- Diagnostic Significance of 3D Automated Breast Volume Scanner in a Combination with Contrast-Enhanced Ultrasound for Breast Cancer.BioMed research international · 2022Article
- Initial Evaluation of Lymphosonography to Identify Sentinel Lymph Nodes in Cervical and Vulvar Cancer Patients.Journal of clinical ultrasound : JCUArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the diagnostic efficacy of sentinel lymph nodes (SLN) in breast cancer by percutaneous contrast-enhanced ultrasound (CEUS) through pooled analysis of relevant studies published before June 2021.
methodsWe conducted a systematic review and meta-analysis of relevant studies by searching the electronic databases of PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang and VIP and the studies were screened according to their inclusion and exclusion criteria. Sensitivity (SEN), specificity (SPE), positive likelihood ratio (+LR), negative likelihood ratio (-LR) and diagnostic odds ratio (DOR) were calculated by Meta-disc 1.4 software and the summary receiver operating characteristic (SROC) curve and area under the curve of ROC (AUC) were constructed.
resultsTwenty-two publications evaluating the diagnostic efficacy of SLN in breast cancer under percutaneous CEUS were included in the meta-analysis. The diagnostic sensitivity, specificity were 0.86 (95% CI: 0.83-0.88) and 0.89 (95% CI: 0.87-0.91) for SLN in breast cancer detected by percutaneous CEUS respectively using a random effect model. The +LR and -LR were combined in a random effect model due to significant statistical heterogeneity (p < 0.05). The pooled +LR, -LR were 7.06 (95% CI: 4.34-11.50), and 0.17 (95% CI: 0.12-0.24), respectively. The combined DOR was 53.32 (95% CI: 29.74-95.61) for SLN diagnosis in breast cancer by percutaneous CEUS under a random effect model. The AUC was 0.94 which indicated that CEUS had high diagnostic efficacy of SLN in patients with breast cancer.
conclusionsCEUS is a noninvasive method for the detection SLN in patients of breast cancer with relative high prediction efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.