Evidence map›Paper›PMID 34605187›Full record

ArticlePhysiological reports2021

Comparison of polynomial fitting versus single time point analysis of ECIS data for barrier assessment.

Karthik Suresh, Laura Servinsky, Laura Johnston, Naresh M Punjabi, Steven M Dudek, Mahendra Damarla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. MK2 nonenzymatically promotes nuclear translocation of caspase-3 and resultant apoptosis.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Karthik SureshDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2920-0949
Laura ServinskyDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Laura JohnstonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Naresh M PunjabiDepartment of Medicine, University of Miami, Coral Gables, FL, USA.
Steven M DudekDepartment of Medicine, University of Illinois, Chicago, IL, USA.
Mahendra DamarlaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Illinois Chicago · USUniversity of Miami · US

Funding

Targeting Divergent Roles of Caspase 3 to Promote Endothelial Barrier IntegrityR01HL133413 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DAMARLA, MAHENDRA · 2016 to 2020
$2.0M
ROS-induced endothelial dysfunction in pulmonary arterial hypertensionK08HL132055 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SURESH, KARTHIK · 2017 to 2021
$828k
NHLBI NIH HHS K08 HL132055NHLBI NIH HHS R01 HL133413
6 · The paper itself

Abstract

Electrical cell-substrate impedance sensing (ECIS) is an in vitro methodology for measuring the barrier integrity of a variety of cell types, including pulmonary endothelial cells. These experiments are frequently used for in vitro assessment of lung injury. The data derived from ECIS experiments consists of repeated measures of resistance across an endothelial monolayer. As such, these data reflect the dynamic changes in electrical resistance that occur over time. Currently methodologies for assessing ECIS data rely on single point assessments of barrier function, such as the maximal drop in trans-endothelial electrical resistance (TER

Indexed as

AnimalsBiosensing TechniquesCell MembraneElectric ImpedanceEndothelial CellsHumansLungMicebarrier functionelectrical cell-substrate impedance sensing

Identifiers

PMID34605187
PMCPMC8488550
OpenAlexW3202707118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.