Evidence map›Paper›PMID 34605006›Full record

ArticleActa neurologica Scandinavica2022

Stroke admissions and revascularization treatments in Denmark during COVID-19.

Nicolas Drenck, Josefine Grundtvig, Thomas Christensen, Helle Klingenberg Iversen, Christina Kruuse, Thomas Truelsen, Troels Wienecke, Hanne Christensen

Abstract read
In one paragraph

Article in Acta neurologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolas DrenckDepartment of Neurology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-7652-5311
Josefine GrundtvigDepartment of Neurology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Thomas ChristensenDepartment of Neurology, Copenhagen University Hospital-Nordsjaellands Hospital, Hillerød, Denmark.
Helle Klingenberg IversenDepartment of Neurology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Christina KruuseDepartment of Neurology, Copenhagen University Hospital-Herlev Gentofte, Copenhagen, Denmark.
Thomas TruelsenDepartment of Neurology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Troels WieneckeDepartment of Neurology, Zealand University Hospital, Roskilde, Denmark.
Hanne ChristensenDepartment of Neurology, Copenhagen University Hospital-Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to assess the number of stroke-related admissions and acute treatments during the first two waves of COVID-19 and lockdowns in the Capital Region of Denmark and the Region of Zealand. MATERIALS &

methodsThe weekly numbers of admitted patients with stroke were retrieved from electronic patient records from January 2019 to February 2021 and analysed to reveal potential fluctuations in patient volumes during the pandemic.

resultsA total of 23,688 patients were included, of whom 2049 patients were treated with tissue-type plasminogen activators (tPA) and 552 underwent endovascular thrombectomy (EVT). We found a transient decrease in the number of weekly admitted patients (pts/week) with all strokes (-9.8 pts/week, 95% CI: -19.4; -0.2, p = .046) and stroke mimics (-30.1 pts/week, 95% CI: -39.9; -20.3, p < .001) during the first lockdown compared to pre-COVID-19. The number of subarachnoid haemorrhage, intracerebral haemorrhage, and ischaemic stroke admissions showed insignificant declines. Analysing all COVID-19 periods collectively revealed increased volumes of ischaemic stroke (+6.2 pts/week, 95% CI: +1.6; +10.7, p = .009) compared to pre-COVID levels, while numbers of stroke mimics remained lower than pre-COVID. Weekly tPA and EVT treatments remained constant throughout the study period.

conclusionsOur results are comparable with other studies in finding reductions in stroke-related admissions early in the pandemic. This is the first study to report increased stroke volumes following the first wave of the pandemic. The mechanisms behind the observed drop and subsequent rise in strokes are unclear and warrant further investigation.

Indexed as

Brain IschemiaCOVID-19StrokeCommunicable Disease ControlDenmarkHumansRetrospective StudiesSARS-CoV-2Thrombolytic TherapyCOVID-19ischaemic strokepandemicstrokethrombectomythrombolysis

Identifiers

PMID34605006
PMCPMC8653351

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.