Evidence map›Paper›PMID 34604934›Full record

ArticleParasitology research2021

Efficacy of carvacryl acetate in vitro and following oral administration to mice harboring either prepatent or patent Schistosoma mansoni infections.

Bianca C Silva, Ana C Mengarda, Vinícius C Rodrigues, Rayssa A Cajas, Paulo U Carnaúba, Maria Cristina C Espírito-Santo, Carlos S M Bezerra-Filho, Damião P de Sousa, Josué de Moraes

Abstract read
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In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Bianca C SilvaNúcleo de Pesquisa Em Doenças Negligenciadas, Universidade Guarulhos, R. Eng. Prestes Maia, 88, Centro, Guarulhos, SP, 07023-070, Brazil.
Ana C MengardaNúcleo de Pesquisa Em Doenças Negligenciadas, Universidade Guarulhos, R. Eng. Prestes Maia, 88, Centro, Guarulhos, SP, 07023-070, Brazil.
Vinícius C RodriguesNúcleo de Pesquisa Em Doenças Negligenciadas, Universidade Guarulhos, R. Eng. Prestes Maia, 88, Centro, Guarulhos, SP, 07023-070, Brazil.
Rayssa A CajasNúcleo de Pesquisa Em Doenças Negligenciadas, Universidade Guarulhos, R. Eng. Prestes Maia, 88, Centro, Guarulhos, SP, 07023-070, Brazil.
Paulo U CarnaúbaNúcleo de Pesquisa Em Doenças Negligenciadas, Universidade Guarulhos, R. Eng. Prestes Maia, 88, Centro, Guarulhos, SP, 07023-070, Brazil.
Maria Cristina C Espírito-SantoLaboratório de Imunopatologia da Esquistossomose (LIM-06), Departamento de Moléstias Infecciosas E Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Carlos S M Bezerra-FilhoDepartamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
Damião P de SousaDepartamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
Josué de MoraesNúcleo de Pesquisa Em Doenças Negligenciadas, Universidade Guarulhos, R. Eng. Prestes Maia, 88, Centro, Guarulhos, SP, 07023-070, Brazil. moraesnpdn@gmail.com.ORCID http://orcid.org/0000-0003-1766-7031
Guarulhos University · BRUniversidade Federal da Paraíba · BRUniversidade de São Paulo · BR

Funding

fundação de amparo à pesquisa do estado de são paulo 2016/22488-3fundação de amparo à pesquisa do estado de são paulo 2019/25289-0fundação de amparo à pesquisa do estado de são paulo 2019/25905-2
6 · The paper itself

Abstract

Schistosomiasis is a major public health problem that afflicts more than 240 million individuals globally, particularly in poor communities. Treatment of schistosomiasis relies heavily on a single oral drug, praziquantel, and there is interest in the search for new antischistosomal drugs. This study reports the anthelmintic evaluation of carvacryl acetate, a derivative of the terpene carvacrol, against Schistosoma mansoni ex vivo and in a schistosomiasis animal model harboring either adult (patent infection) or juvenile (prepatent infection) parasites. For comparison, data obtained with gold standard antischistosomal drug praziquantel are also presented. Initially in vitro effective concentrations of 50% (EC

Indexed as

Schistosomiasis mansoniSchistosomicidesAdministration, OralAnimalsMiceMonoterpenesSchistosoma mansonicarvacryl acetateMonoterpenesSchistosomicidesAntischistosomal activityCarvacryl acetateSchistosomaSchistosomiasis

Identifiers

PMID34604934
OpenAlexW3203934140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.