Evidence map›Paper›PMID 34604910›Full record

ArticleSleep2022

Symptoms of obstructive sleep apnea are associated with less frequent exercise and worse subjective cognitive function across adulthood.

Miranda G Chappel-Farley, Bryce A Mander, Ariel B Neikrug, Annamarie Stehli, Bin Nan, Joshua D Grill, Michael A Yassa, Ruth M Benca

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03860857 (The BEACoN Study- Biomarker Exploration in Aging, Cognition and Neurodegeneration), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03860857 phase3recruitingnot on this map

The BEACoN Study- Biomarker Exploration in Aging, Cognition and Neurodegeneration

TypeinterventionalSponsorUniversity of California, IrvineRan2018 to 2027Enrolled300ConditionsAlzheimer Disease, Cognitive Impairment, Cognitive DeclineArmsAmyloid PET scan, Tau PET scan using MK-6240, Neurocognitive testing, MRI
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Miranda G Chappel-FarleyDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0003-1349-0507
Bryce A ManderCenter for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, USA.
Ariel B NeikrugDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Annamarie StehliDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA.
Bin NanCenter for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA, USA.
Joshua D GrillDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Michael A YassaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Ruth M BencaDepartment of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Seyed Ahmad Sajjadi · 2020 to 2026
$27.9M
Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adultsK01AG068353 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MANDER, BRYCE A. · 2020 to 2024
$636k
Neurobiological mechanisms of sleep and exercise effects on memory in older adults at risk for Alzheimer's diseaseF31AG074703 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHAPPEL-FARLEY, MIRANDA · 2021 to 2023
$111k
NCATS NIH HHS UL1 TR001414NIA NIH HHS F31 AG074703NIA NIH HHS K01 AG068353NIA NIH HHS NIA F31AG074703NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG053555NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

STUDY

objectivesTo determine whether subjective measures of exercise and sleep are associated with cognitive complaints and whether exercise effects are mediated by sleep.

methodsThis study analyzed questionnaire data from adults (18-89) enrolled in a recruitment registry. The Cognitive Function Instrument (CFI) assessed cognitive complaints. Medical Outcomes Study Sleep Scale (MOS-SS) subscales and factor scores assessed sleep quality, daytime sleepiness, nighttime disturbance, and insomnia and obstructive sleep apnea (OSA)-like symptoms. Exercise frequency was defined as the weekly number of exercise sessions. Exercise frequency, MOS-SS subscales, and factor scores were examined as predictors of CFI score, adjusting for age, body mass index, education, sex, cancer diagnosis, antidepressant usage, psychiatric conditions, and medical comorbidities. Analyses of covariance examined the relationship between sleep duration groups (short, mid-range, and long) and CFI score, adjusting for covariates. Mediation by sleep in the exercise-CFI score relationship was tested.

resultsData from 2106 adults were analyzed. Exercise and MOS-SS subscales and factor scores were associated with CFI score. Higher Sleep Adequacy scores were associated with fewer cognitive complaints, whereas higher Sleep Somnolence, Sleep Disturbance, Sleep Problems Index I, Sleep Problems Index II, and factor scores were associated with more cognitive complaints. MOS-SS subscales and factor scores, except Sleep Disturbance and the insomnia factor score, mediated the association between exercise and cognitive complaints.

conclusionsThe relationship between exercise frequency and subjective cognitive performance is mediated by sleep. In particular, the mediation effect appears to be driven by symptoms possibly suggestive of OSA which are negatively associated with exercise engagement, sleep quality, daytime sleepiness, and subjective cognitive performance.

Indexed as

Disorders of Excessive SomnolenceSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersAdultCognitionHumansSleepinessSurveys and Questionnairesagingcognitive complaintsexerciseinsomniaobstructive sleep apneasleepsubjective cognitive function

Identifiers

PMID34604910
PMCPMC8919199
OpenAlexW3204034826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.