ArticleJACS Au2021
Selection between Competing Self-Reproducing Lipids: Succession and Dynamic Activation.
Article in JACS Au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- The dynamic chemistry of the boron-nitrogen bond.Chemical science · 2026Article
- Abiotic lipid metabolism enables membrane plasticity in artificial cells.Nature chemistry · 2025Article
- Amplification of Asymmetry via Structural Transitions in Supramolecular Polymer-Surfactant Coassemblies.Journal of the American Chemical Society · 2025Article
- A Chemical Reaction Network Drives Complex Population Dynamics in Oscillating Self-Reproducing Vesicles.Journal of the American Chemical Society · 2024Article
- From autocatalysis to survival of the fittest in self-reproducing lipid systems.Nature reviews. Chemistry · 2023Review
- Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.Journal of the American Chemical Society · 2023Article
- Transient self-assembly of metal-organic complexes.Chemical science · 2023Article
- Anion-assisted amidinium exchange and metathesis.Chemical communications (Cambridge, England) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Models of chemical evolution are central to advancing origins of life research. To design more lifelike systems, we must expand our understanding of molecular selection mechanisms. Here, we show two selection modes that produce evolving populations of self-reproducing species, formed through thiol-disulfide exchange. Competition between thiol precursors can give clear succession patterns based on steric factors, an intrinsic property. A separate, emergent selection mechanism-dynamic activating metathesis-was found when exploring competing disulfide precursors. These experiments reveal that additional species generated in the mixture open up alternative reaction pathways to form self-reproducing products. Thus, increased compositional complexity provides certain species with a unique competitive advantage at the expense of others.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.