ArticleHGG advances2021
Genetic discovery and risk characterization in type 2 diabetes across diverse populations.
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Article in HGG advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
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- The accuracy of polygenic score models for BMI and Type II diabetes in the Native Hawaiian population.Communications biology · 2025Article
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- Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations.Diabetologia · 2024Article
- Genetics of glucose homeostasis in pregnancy and postpartum.Diabetologia · 2024Article
- Native Hawaiian and Pacific Islander populations in genomic research.NPJ genomic medicine · 2024Review
- Enhancing Genetic Risk Prediction through Federated Semi-Supervised Transfer Learning with Inaccurate Electronic Health Record Data.Statistics in biosciences · 2024Article
- Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.Science (New York, N.Y.) · 2024Article
- Article
- Polygenic Risk for Type 2 Diabetes in African Americans.Diabetes · 2024Article
- AI-enhanced integration of genetic and medical imaging data for risk assessment of Type 2 diabetes.Nature communications · 2024Article
- Evaluating the Efficacy of Type 2 Diabetes Polygenic Risk Scores in an Independent European Population.International journal of molecular sciences · 2024Article
- Insights from rare variants into the genetic architecture and biology of youth-onset type 2 diabetes.Research square · 2023Article
Corrections and comments
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Authors and funding
57 authors at 20 institutions in 3 countries.
Linda M PolfusDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Burcu F DarstDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Heather HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xin ShengDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Maggie C Y NgDivision of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer E BelowThe Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Lauren PettyThe Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Stephanie BienAdaptive Biotechnologies Corporation, Seattle, WA, USA.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Wei Wang23andMe, Sunnyvale, CA, USA.
Pierre Fontanillas23andMe, Sunnyvale, CA, USA.
Yesha PatelDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
23andMe Research Team
DIAMANTE Hispanic/Latino Consortium
MEta-analysis of type 2 DIabetes in African Americans Consortium
Michael PreussIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Claudia SchurmannIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Zhaohui DuDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Yingchang LuDivision of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Suhn K RhieDepartment of Biochemistry and Molecular Medicine, University of Southern California, Los Angeles, CA, USA.
Joseph M MercaderProgram in Metabolism, Broad Institute, Cambridge, MA, USA.
Teresa Tusie-LunaUnidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de Mexico, Mexico City, Mexico.
Clicerio González-VillalpandoCentro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico.
Lorena OrozcoInstituto Nacional de Medicina Genómica, Mexico City, Mexico.
Cassandra N SpracklenDepartment of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA.
Brian E CadeDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Richard A JensenCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Meng SunWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK, USA.
Yoonjung Yoonie JooDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ping AnDivision of Statistical Genomics, School of Medicine, Washington University, St. Louis, MO, USA.
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Salman TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Aude NicolasLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of Health, Bethesda, MD, USA.
Laura RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Wei-Min ChenDepartment of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Girish N NadkarniIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ran TaoDepartment of Biostatistics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Martha DaviglusInstitute for Minority Health Research, University of Illinois Chicago, Chicago, IL, USA.
Qibin QiCenter for Population Cohorts, Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Eric A BoerwinkleHuman Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
Simin LiuSchool of Public Health, Brown University, Providence, RI, USA.
Lawrence S PhillipsAtlanta VA Medical Center, Decatur, GA, USA.
Ulrike PetersDivision of Public Health Sciences, University of Washington, Department of Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chris CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lynne R WikensUniversity of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Steven BuyskeDepartment of Statistics, Rutgers University, Piscataway, NJ, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ruth J F LoosIcahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, The Charles Bronfman Institute for Personalized Medicine, New York, NY, USA.
Daniel O StramDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
Christopher A HaimanDepartment of Preventive Medicine, Center for Genetic Epidemiology, University of Southern California, Los Angeles, CA, USA.
University of Southern California · USUniversity of North Carolina at Chapel Hill · USVanderbilt University Medical Center · USIcahn School of Medicine at Mount Sinai · US23andMe (United States) · USFred Hutch Cancer Center · USNational Institutes of Health · USAdaptive Biotechnologies (United States) · USAtlanta VA Medical Center · USBroad Institute · USBrown University · USCircadian (United States) · USInstituto Nacional de Salud Pública · MXJohns Hopkins University · USNational Institute of Genomic Medicine · MXNational Institute on Aging · USNational University of Singapore · SGNorthwestern University · USRutgers, The State University of New Jersey · USThe Lundquist Institute · US
Funding
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MNew York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8MPAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5MHispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8MDevelopment of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Multiple AncestriesU01HG011723 · NHGRI · BROAD INSTITUTE, INC. · PI Alisa Knodle Manning, Josep Maria Mercader · 2021 to 2026
$5.7MGenetic programming of human islet metabolic and endoplasmic reticulum (ER) stress responses in diabetesR01DK118011 · NIDDK · JACKSON LABORATORY · PI Michael Lee Stitzel · 2021 to 2026
$4.9MResilience to obesity in carriers of monogenic obesity mutations - a study on the underlying mechanismsR01DK124097 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2020 to 2023
$2.9MHarnessing the power of genetic relatedness for disease gene discoveryR01GM133169 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BELOW, JENNIFER, HUFF, CHAD DANIEL · 2019 to 2022
$2.6MPAGE III: Population Architecture using Genomics and EpidemiologyR56HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, HAIMAN, CHRISTOPHER ALAN · 2018 to 2018
$1.0MWhole Genomic Characterization of Sleep Apnea Traits and Comorbid DisordersK01HL135405 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CADE, BRIAN EDMAND · 2017 to 2020
$695kBLRD VA I01 BX005831CSRD VA I01 CX001737NCI NIH HHS P30 CA071789NHGRI NIH HHS R01 HG010297NHGRI NIH HHS R56 HG010297NHGRI NIH HHS U01 HG011723NHLBI NIH HHS K01 HL135405NHLBI NIH HHS R01 HL142302NIDDK NIH HHS L30 DK126146NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R01 DK118011NIDDK NIH HHS R01 DK124097NIGMS NIH HHS R01 GM133169
Abstract
Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been conducted primarily in individuals of European ancestry. We conducted a multiethnic genome-wide association study of T2D among 53,102 cases and 193,679 control subjects from African, Hispanic, Asian, Native Hawaiian, and European population groups in the Population Architecture Genomics and Epidemiology (PAGE) and Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortia. In individuals of African ancestry, we discovered a risk variant in the
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