ArticleJACC. CardioOncology2021
Coronary Artery Disease in Young Women After Radiation Therapy for Breast Cancer: The WECARE Study.
Article in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 64 citations in OpenAlex.
- Review
- Dyslipidaemias in cancer patients.European heart journal · 2026Review
- Radiobiological effects of flattening filter and flattening filter free radiotherapy x-ray on inflammatory and apoptotic pathways in cardiac and pulmonary tissues in an MCF-7 xenograft breast cancer model.Journal of radiation research · 2026Article
- Using deformable registration to assess dosimetric impact of variability in deep inspiration breath hold (DIBH) levels for left breast treatment.Journal of applied clinical medical physics · 2026Article
- Long-Term Risk of Cardiovascular Disease After Contemporary Left-Sided Breast Radiation Therapy.JAMA network open · 2026Article
- MyoNet: Deep Learning-Based Myocardial Strain Quantification from Cine Cardiac MRI.Bioengineering (Basel, Switzerland) · 2026Article
- Association of radiotherapy with atrial fibrillation-related gene expression in breast cancer patients: a study based on the TCGA-BRCA database.Discover oncology · 2026Article
- Association of cancer treatment with excess heart age among five-year young breast cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Treatment of left ventricular dysfunction during cancer therapy: a comprehensive review.Drugs in context · 2026Review
- Cardiovascular disease risk following radiotherapy among breast cancer survivors: a nationwide cohort study in South Korea.Breast cancer research : BCR · 2025Article
- Polygenic risk of coronary artery disease for long-term survivors of breast cancer.Journal of the National Cancer Institute · 2025Article
- Postmastectomy Radiation Therapy: An ASTRO/ASCO/SSO Clinical Practice Guideline.Annals of surgical oncology · 2025Article
- Effects of Proton Therapy on Cardiac Fibrosis, Calcium Homeostasis, and AQP4 Expression in Hypergravity-Exposed Rats.International journal of molecular sciences · 2025Article
- Cardio-Oncology Considerations for Breast Cancer: Risk Stratification, Monitoring, and Treatment.Oncology (Williston Park, N.Y.) · 2025Review
- Radiation-Induced Cardiotoxicity in Hypertensive Salt-Sensitive Rats: A Feasibility Study.Life (Basel, Switzerland) · 2025Article
- Impact of Endocrine Therapy on Osteoporosis Risk in Women with Breast Cancer Across Different Hormonal Stages: A Review.Current oncology (Toronto, Ont.) · 2025Review
- Atrial Fibrillation in Patients with Breast Cancer: A Literature Review.Cardiology and therapy · 2025Review
- Prevention of cancer-therapy related cardiac dysfunction.Current heart failure reports · 2025Review
- Advances in mitochondrial dysfunction in radiation tissue injury.Frontiers in physiology · 2025Review
- The impact of breast cancer radiation therapy exposure on the prevalence of breast arterial calcification.The British journal of radiology · 2024Article
Corrections and comments
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Authors and funding
22 authors at 13 institutions in 3 countries.
Funding
Abstract
backgroundRadiation therapy (RT) for breast cancer increases risk of coronary artery disease (CAD). Women treated for left- vs right-sided breast cancer receive greater heart radiation exposure, which may further increase this risk. The risk of radiation-associated CAD specifically among younger breast cancer survivors is not well defined.
objectivesThe purpose of this study was to report CAD risk among participants in the Women's Environmental Cancer and Radiation Epidemiology Study.
methodsA total of 1,583 women who were <55 years of age when diagnosed with breast cancer between 1985 and 2008 completed a cardiovascular health questionnaire. Risk of radiation-associated CAD was evaluated by comparing women treated with left-sided RT with women treated with right-sided RT using multivariable Cox proportional hazards models. Effect modification by treatment and cardiovascular risk factors was examined
resultsIn total, 517 women who did not receive RT and 94 women who had a pre-existing cardiovascular disease diagnosis were excluded, leaving 972 women eligible for analysis. Their median follow-up time was 14 years (range 1-29 years). The 27.5-year cumulative incidences of CAD for women receiving left- vs right-sided RT were 10.5% and 5.8%, respectively
conclusionsYoung women treated with RT for left-sided breast cancer had over twice the risk of CAD compared with women treated with RT for right-sided breast cancer. Laterality of RT is independently associated with an increased risk of CAD and should be considered in survivorship care of younger breast cancer patients.
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