Evidence map›Paper›PMID 34604797›Full record

ReviewJACC. CardioOncology2021

Cardiovascular Manifestations From Therapeutic Radiation: A Multidisciplinary Expert Consensus Statement From the International Cardio-Oncology Society.

Joshua D Mitchell, Daniel A Cehic, Marita Morgia, Carmen Bergom, Joanne Toohey, Patricia A Guerrero, Maros Ferencik, Robin Kikuchi, Joseph R Carver, Vlad G Zaha and 9 more

Open access · goldAbstract readReview
In one paragraph

Review in JACC. CardioOncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 2 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Guideline
  2. American Radium Society Appropriate Use Criteria on Cardiac Toxicity Prevention and Management After Thoracic Radiotherapy.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2024
    Pooled it
  3. Dyslipidaemias in cancer patients.European heart journal · 2026
    Review
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 2 countries.

Joshua D MitchellCardio-Oncology Center of Excellence, Washington University in St. Louis, St. Louis, Missouri, USA.
Daniel A CehicGenesisCare, Australia.
Marita MorgiaNorthern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Carmen BergomCardio-Oncology Center of Excellence, Washington University in St. Louis, St. Louis, Missouri, USA.
Joanne TooheyDepartment of Radiation Oncology, GenesisCare, St. Vincent's Hospital, Sydney, New South Wales, Australia.
Patricia A GuerreroAdventHealth Orlando Cardiovascular Institute, Orlando, Florida, USA.
Maros FerencikKnight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon, USA.
Robin KikuchiDivision of Medical Oncology, Duke Cancer Institute, Duke University, Durham, North Carolina, USA.
Joseph R CarverAbramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Vlad G ZahaCardiology Division, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jose A Alvarez-CardonaCardio-Oncology Center of Excellence, Washington University in St. Louis, St. Louis, Missouri, USA.
Sebastian SzmitDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre, Otwock, Poland.
Andrés J DanieleRoffo Institute, Buenos Aires, Argentina.
Juan Lopez-MatteiDepartments of Cardiology and Thoracic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Lili ZhangCardio-Oncology Program, Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Jörg HerrmannDepartment of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Anju NohriaCardio-Oncology Program, Dana Farber Cancer Institute/Brigham and Women's Hospital, Boston, Massachusetts, USA.
Daniel J LenihanCardio-Oncology Center of Excellence, Washington University in St. Louis, St. Louis, Missouri, USA.
Susan F DentDivision of Medical Oncology, Duke Cancer Institute, Duke University, Durham, North Carolina, USA.
Washington University in St. Louis · USDuke Medical Center · USAdventHealth Orlando · USAlbert Einstein College of Medicine · USAustralian and New Zealand Intensive Care Society · AUBrigham and Women's Hospital · USMayo Clinic · USOregon Health & Science University · USParkland Health & Hospital System · USRoyal North Shore Hospital · AUSt Vincent's Hospital Sydney · AUThe University of Texas MD Anderson Cancer Center · USUniversity of Pennsylvania · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Genetic Modifiers of Radiation Therapy-Induced CardiotoxicityR01HL147884 · NHLBI · WASHINGTON UNIVERSITY · PI BERGOM, CARMEN · 2019 to 2023
$2.3M
NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R01 HL147884
6 · The paper itself

Abstract

Radiation therapy is a cornerstone of cancer therapy, with >50% of patients undergoing therapeutic radiation. As a result of widespread use and improved survival, there is increasing focus on the potential long-term effects of ionizing radiation, especially cardiovascular toxicity. Radiation therapy can lead to atherosclerosis of the vasculature as well as valvular, myocardial, and pericardial dysfunction. We present a consensus statement from the International Cardio-Oncology Society based on general principles of radiotherapy delivery and cardiovascular risk assessment and risk mitigation in this population. Anatomical-based recommendations for cardiovascular management and follow-up are provided, and a priority is given to the early detection of atherosclerotic vascular disease on imaging to help guide preventive therapy. Unique management considerations in radiation-induced cardiovascular disease are also discussed. Recommendations are based on the most current literature and represent a unanimous consensus by the multidisciplinary expert panel.

Indexed as

aHR, adjusted hazard ratioCABG, coronary artery bypass graftCAC, coronary artery calciumCAD, coronary artery diseasecancercardiovascular diseaseCI, confidence intervalCTCA, computed tomography coronary angiographyCT, computed tomographyCV, cardiovascularDIBH, deep inspiratory breath holdHF, heart failureHL, Hodgkin lymphomaHNC, head and neck cancerHR, hazard ratioimagingLIMA, left internal mammary arteryMRI, magnetic resonance imagingNT-proBNP, N-terminal pro–B-type natriuretic peptideOR, odds ratioPAD, peripheral arterial diseasepreventionradiation therapyRT, radiation therapySAVR, surgical aortic valve replacementscreeningSVC, superior vena cavaTAVR, transcatheter aortic valve replacementTTE, transthoracic echocardiogram

Identifiers

PMID34604797
PMCPMC8463721
OpenAlexW3200414736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.