ArticleACS omega2021
Glucose-Based Fluorinated Surfactants as Additives for the Crystallization of Membrane Proteins: Synthesis and Preliminary Physical-Chemical and Biochemical Characterization.
Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 6 citations in OpenAlex.
- Improved Pendant-Bearing Glucose-Neopentyl Glycols for Membrane Protein Stability.Bioconjugate chemistry · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report herein the synthesis of a series of fluorinated surfactants with a glucose moiety as a polar head group and whose alkyl chain was varied in length and in fluorine/hydrogen ratio. They were synthesized in two or four steps in 20 to 50% overall yields allowing gram-scale synthesis. Their solubility in water is between 0.2 and 13.8 g/L, which indicates low water solubility. Two derivatives of the series were found to form micelles in water at ∼11 mM. Their hydrophilic-lipophilic balance was determined both by Griffin's and Davies' methods; they may exhibit a "harsh" character toward membrane proteins. This, combined with their low water solubility, suggest that they could advantageously be used in detergent mixtures containing a "mild" detergent. Finally, the potency of one of the derivatives, F
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Registered trials
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