Evidence map›Paper›PMID 34604607›Full record

ArticleAdvances in radiation oncology

A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer.

Dong Han, Hamed Hooshangnejad, Chin-Cheng Chen, Kai Ding

Open access · goldAbstract read
In one paragraph

Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dong HanDepartments of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Hamed HooshangnejadDepartments of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland.
Chin-Cheng ChenDepartments of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Proton Therapy Center, Washington, District of Columbia.
Kai DingDepartments of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland.
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

Spacer Enabled Robust Radiation Therapy (SERRT)R37CA229417 · NCI · JOHNS HOPKINS UNIVERSITY · PI DING, KAI · 2018 to 2021
$1.5M
NCI NIH HHS R37 CA229417
6 · The paper itself

Abstract

purposeWe investigate two margin-based schemes for optimization target volumes (OTV), both isotropic expansion (2 mm) and beam-specific OTV, to account for uncertainties due to the setup errors and range uncertainties in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as 2-mm being one of the extreme sizes of margin, we also study whether the plan quality of 2-mm uniform expansion could be comparable to other plan schemes. METHODS AND MATERIALS: We developed 2 schemes for OTV: (1) a uniform expansion of 2 mm (OTV

resultsAll 3 optimization schemes achieved decent target coverage with no significant difference. The OTV

conclusionsThe use of OTV

Identifiers

PMID34604607
PMCPMC8463829
OpenAlexW3188173475

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.