Evidence map›Paper›PMID 34604548›Full record

ArticleBiochemistry and biophysics reports2021

Association of the myosin heavy chain 9 gene single nucleotide polymorphism with inflammatory bowel disease.

Ahmed Ezz El-Arab Abd Al-Aliem, Eman A E Badr, Elsayed Ibrahem El-Shayeb, Ahmed Megahed Ahmed Taman, Abd El-Naser Abd El-Atty Gadallah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ahmed Ezz El-Arab Abd Al-AliemDepartment of Internal Medicine, Faculty of Medicine, Menoufia University, Egypt.
Eman A E BadrDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Egypt.
Elsayed Ibrahem El-ShayebDepartment of Internal Medicine, Faculty of Medicine, Menoufia University, Egypt.
Ahmed Megahed Ahmed TamanDepartment of Internal Medicine, Faculty of Medicine, Menoufia University, Egypt.
Abd El-Naser Abd El-Atty GadallahDepartment of Internal Medicine, Faculty of Medicine, Menoufia University, Egypt.
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, the cause of inflammatory bowel disease (IBD) remains a mystery. A balance between cell proliferation and apoptosis maintains intestinal tissue homeostasis. Dissociation-induced myosin-actin contraction results in stem cell apoptosis. This study aiming to evaluate the influence of the myosin heavy chain 9 ( SUBJECTS:

resultsOn analyzing rs3752462 CT and TT genotypes were significantly more frequent in IBD patients as compared to controls with 4.6 fold increase in the risk of IBD. While on analyzing rs4821480, The TG and GG genotypes have significant increased distribution among the IBD patients as compared to the controls with 5.3 fold increase in the risk of IBD and higher prevalence of GG genotype in patients with low hemoglobin level and higher BMI.

conclusionThe rs3752462 T allele and rs4821480 G allele of

Indexed as

IBDMYH9SNP

Identifiers

PMID34604548
PMCPMC8473667
OpenAlexW3201118596

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.