ArticleReports of biochemistry & molecular biology2021
The Correlation between Selenium-Dependent Glutathione Peroxidase Activity and Oxidant/Antioxidant Balance in Sera of Diabetic Patients with Nephropathy.
Article in Reports of biochemistry & molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- A bibliometric analysis of trace elements and diabetic kidney disease: scientific hotspots and research evolution.Renal failure · 2026Review
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- Methamphetamine-Induced Oxidative Stress and Inflammatory Markers as Indicators of Blood-Brain Barrier Disruption.Reports of biochemistry & molecular biology · 2025Article
- Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms.Indian journal of clinical biochemistry : IJCB · 2025Review
- How to assess antioxidant activity? Advances, limitations, and applications of in vitro, in vivo, and ex vivo approaches.Food production, processing and nutrition · 2025Review
- A new therapy to alleviate the inflammatory injury of piglet intestine caused by short-distance transportation--music.PloS one · 2025Article
- Potential Effects of Selenium and N-Acetylcysteine Supplementation in Ameliorating Cardinal Symptoms of Nω-Nitro-L-Arginine Methyl Ester Hydrochloride (L-NAME) Induced Preeclampsia in Wistar Rats.Reports of biochemistry & molecular biology · 2025Article
- Usefulness of A Random Spot Urine Proteins-to-Creatinine Ratio to Screen for Increased Albuminuria in Patients with Type 1 Diabetes.Reports of biochemistry & molecular biology · 2025Article
- Evaluation of Paraoxonase-1 Activity of Arylesterase and Lactonase and Their Correlation with Oxidative Stress in Children with Type 1 Diabetes Mellitus.Reports of biochemistry & molecular biology · 2024Article
- Pro-Oxidant/ Antioxidant Balance Correlates with Red Blood Cell Indices and Anemia Severity in the Anemic Patients.Reports of biochemistry & molecular biology · 2024Article
- Pathomechanisms of Diabetic Kidney Disease.Journal of clinical medicine · 2023Review
- Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies.International journal of molecular sciences · 2023Review
- Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections.International journal of molecular sciences · 2023Review
- TheReports of biochemistry & molecular biology · 2023Article
- The Effects ofInternational journal of molecular sciences · 2023Review
- Effects of short-distance transportation on physiological indexes, intestinal morphology, microbial community, and the transcriptome of the jejunum in weaned piglets.Frontiers in veterinary science · 2023Article
- Article
- Comparative Study of New Biomarkers in Iraqi DM2 with and without Complications.Reports of biochemistry & molecular biology · 2022Article
- Importance of Microminerals for Maintaining Antioxidant Function After COVID-19-induced Oxidative Stress.Reports of biochemistry & molecular biology · 2022Article
- Role of c-miR-21, c-miR-126, Redox Status, and Inflammatory Conditions as Potential Predictors of Vascular Damage in T2DM Patients.Antioxidants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress is an imbalance between free radical's production and the body's ability to counteract or detoxify their harmful effects through neutralization by antioxidants, oxidative stress is thought to be involved in the pathogenesis of diabetic nephropathy. One of the key enzymatic antioxidants is glutathione peroxidase (GPx), which plays an important protective function in diabetes complications, by reducing the rising state of oxidative stress and removing toxicity from peroxides and converting them into a non-toxic substance. The objective of this research was to evaluate the rule of glutathione peroxidase in regulate oxidants/antioxidants levels diabetic patients with nephropathy.
methodsIn a case-control study, we assessed serum GPx activity (Se-Dependent, non-selenium dependent and total GPx), total oxidant, lipid peroxidation, total antioxidant, and catalase in healthy control subjects (group 1), in diabetic patients without diabetic nephropathy (group 2) and diabetic patients with nephropathy (group 3).
resultsGPx activity was significantly lower in T2D patients with and without nephropathy compared to healthy subject's control. Total oxidants and lipids peroxidation have a negative correlation with the GPx and other antioxidants.
conclusionDecreased GPx activity indicate a relationship between GPx activity and diabetic nephropathy.
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