Evidence map›Paper›PMID 34604246›Full record

ArticleFrontiers in medicine2021

Combination of 0.05% Azelastine and 0.1% Tacrolimus Eye Drops in Children With Vernal Keratoconjunctivitis: A Prospective Study.

Minjie Chen, Anji Wei, Bilian Ke, Jun Zou, Lan Gong, Yan Wang, Chaoran Zhang, Jianjiang Xu, Jia Yin, Jiaxu Hong

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06903884 (A Randomized Controlled Trial of 3% Diquafosol Ophthalmic Solution for Active Moderate-to-Severe Vernal Keratoconjunctivitis), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06903884 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomized Controlled Trial of 3% Diquafosol Ophthalmic Solution for Active Moderate-to-Severe Vernal Keratoconjunctivitis

TypeinterventionalSponsorThe University of Hong KongRan2026 to 2028Enrolled94ConditionsVernal KeratoconjunctivitisArms3% Diquafosol ophthalmic solution and 0.1% Cyclosporin A cationic ophthalmic emulsion, 0.1% Cyclosporin A cationic ophthalmic emulsion
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Vernal Keratoconjunctivitis: A Systematic Review.Clinical reviews in allergy & immunology · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Minjie ChenDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Anji WeiDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Bilian KeDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Jun ZouDepartment of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Lan GongDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Yan WangDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Chaoran ZhangDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Jianjiang XuDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Jia YinMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.
Jiaxu HongDepartment of Ophthalmology, Eye and Ear, Nose, and Throat Hospital of Fudan University, Shanghai, China.
Fudan University · CNAffiliated Hospital of Guizhou Medical University · CNHarvard University · USShanghai First People's Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

azelastineocular surface disease indexpalpebral conjunctival papillaetacrolimusvernal conjunctivitis

Identifiers

PMID34604246
PMCPMC8484704
OpenAlexW3201515236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.