Evidence map›Paper›PMID 34604230›Full record

ReviewFrontiers in cell and developmental biology2021

Primordial Germ Cell Specification in Vertebrate Embryos: Phylogenetic Distribution and Conserved Molecular Features of Preformation and Induction.

Christina L Hansen, Francisco Pelegri

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. How germ granules promote germ cell fate.Nature reviews. Genetics · 2024
    Review
  12. Article
  13. Review
  14. Male Germ Cell Specification in Plants.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Article
  17. Frontiers in cell and developmental biology · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christina L HansenLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, United States.
Francisco PelegriLaboratory of Genetics, University of Wisconsin-Madison, Madison, WI, United States.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Diversity Supplement: Cytokinesis and RNA segregation in zebrafish developmentR01GM065303 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PELEGRI, FRANCISCO J · 2002 to 2023
$4.7M
NIGMS NIH HHS R01 GM065303NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

The differentiation of primordial germ cells (PGCs) occurs during early embryonic development and is critical for the survival and fitness of sexually reproducing species. Here, we review the two main mechanisms of PGC specification, induction, and preformation, in the context of four model vertebrate species: mouse, axolotl,

Indexed as

embryonic developmentgerm cellsgermline specificationinductionpreformationprimordial germ cells (PGCs)

Identifiers

PMID34604230
PMCPMC8481613

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.